Smad2 and Smad4 gene mutations in hepatocellular carcinoma

被引：0
|
作者：
M C Yakicier
M B Irmak
A Romano
M Kew
M Ozturk
机构：
[1] Bilkent University,Department of Molecular Biology and Genetics
[2] University of The Witwatersrand,undefined
[3] Institute of Molecular Pathology,undefined
来源：
Oncogene | 1999年 / 18卷
关键词：
hepatocellular carcinoma; Smad2; Smad4; TGFβ; tumor suppressor genes; somatic mutation;
D O I：
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中图分类号：
学科分类号：
摘要：
TGF-β is a negative regulator of liver growth. Smad family of genes, as mediators of TGF-β pathway, are candidate tumor suppressor genes in hepatocellular carcinoma (HCC). We studied 35 HCC and non-tumour liver tissues for possible mutations in Smad2 and Smad4 genes. Three tumours displayed somatic mutations; two in Smad4 (Asp332Gly and Cys401Arg) and one in Smad2 (Gln407Arg) genes. All three mutations were A:T → G:C transitions suspected to result from oxidative stress as observed in mitochondrial DNA. These observation demonstrate that TGF-β pathway is altered in hepatocellular carcinoma.
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页码：4879 / 4883
页数：4
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