Variability of coumarin 7- and 3-hydroxylation in a Jordanian population is suggestive of a functional polymorphism in cytochrome P450 CYP2A6

被引：0
|
作者：
H. Hadidi
Y. Irshaid
C. Broberg Vågbø
A. Brunsvik
S. Cholerton
K. Zahlsen
J. R. Idle
机构：
[1] Department of Medical Genetics,
[2] Regional Hospital in Trondheim,undefined
[3] Eirik Jarls Gate 10,undefined
[4] N-7006 Trondheim,undefined
[5] Norway e-mail: jeffreyi@medisin.ntnu.no Tel.: +47 73 598879 Fax: +47 73 590560,undefined
[6] Department of Pharmacology,undefined
[7] Faculty of Medicine,undefined
[8] Jordan University of Science and Technology,undefined
[9] Irbid,undefined
[10] Jordan,undefined
[11] Department of Pharmacological Sciences,undefined
[12] Medical School,undefined
[13] Newcastle upon Tyne,undefined
[14] UK,undefined
来源：
European Journal of Clinical Pharmacology | 1998年 / 54卷
关键词：
Key words Coumarin; Metabolism; Risk evaluation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Objective: To determine the variability of coumarin 7- and 3-hydroxylation in a human population and to evaluate the evidence for the existence of genetic polymorphism in these pathways. 7-Hydroxylation of coumarin is considered to be a detoxication pathway, whilst 3-hydroxylation, which predominates in rats, leads to hepatotoxicity in the rat. Coumarin metabolic phenotypes could aid in refining the risk evaluation for humans of dietary and environmental exposure to coumarin and for the chronic use of coumarin in high doses as a drug to treat lymphoedema and certain cancers.
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页码：437 / 441
页数：4
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