Comparative transcriptome analysis providing inhibitory mechanism of lung cancer A549 cells by radioactive 125I seed

被引：0
|
作者：
Fang Liu
Jie Bao
Jinwu Chen
Wencheng Song
机构：
[1] Chinese Academy of Sciences,Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health & Medical Technology, Hefei Institutes of Physical Science
[2] Anhui University,School of Life Science
[3] Hefei Cancer Hospital,Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions and School for Radiological and Interdisciplinary Sciences
[4] Chinese Academy of Sciences,undefined
[5] Hefei Normal University,undefined
[6] Soochow University,undefined
来源：
Journal of Radioanalytical and Nuclear Chemistry | 2021年 / 330卷
关键词：
I seed; Transcriptome; Inhibitory mechanism; A549 cells;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In this study, A549 cells treated by radioactive 125I seed were sequenced using Illumina HiSeq PE150, and then the transcriptome was analyzed using bioinformatics methods. Gene ontology classification analysis showed that differentially expressed genes (DEGs) belonged to 10 categories, and low-dose group, medium-dose group and high-dose group 125I treatment obtained 440 DEGs, 4275 DEGs and 2850 DEGs, respectively. Additionally, DEGs were involved in tumor-related pathways, endoplasmic reticulum protein processing and cell cycle pathways. Therefore, radioactive 125I seed can significantly inhibit the growth of lung cancer, which provide a theoretical basis for the clinical 125I seed to effectively treat lung cancer.
引用
收藏
页码：821 / 831
页数：10
相关论文
共 50 条
  • [31] Efficacy of Gefitinib Combined with 125I Radioactive Particles in the Treatment of Transplanted Lung Cancer Tumors in Nude Mice
    Chaojie Li
    Linyan Yao
    Ju Gong
    Haopeng Pang
    Qungang Shan
    Ziyin Wang
    Jian Lu
    Zhongmin Wang
    CardioVascular and Interventional Radiology, 2020, 43 : 1364 - 1370
  • [32] Trans-bronchoscopy with implantation of 125I radioactive seeds in patients with pulmonary atelectasis induced by lung cancer
    Lu, Mingjian
    Pu, Deli
    Zhang, Weidong
    Liao, Jiangrong
    Zhang, Tao
    Yang, Guang
    Liu, Zhenyin
    Singh, Sristi
    Gao, Fei
    Zhang, Fujun
    ONCOLOGY LETTERS, 2015, 10 (01) : 216 - 222
  • [33] Synthesis of Novel Xanthone Analogues and Their Growth Inhibitory Activity Against Human Lung Cancer A549 Cells
    Wu, Junqi
    Dai, Jinwei
    Zhang, Yuyang
    Wang, Jing
    Huang, Lei
    Ding, Hongmei
    Li, Tiejun
    Zhang, Yuefan
    Mao, Junqin
    Yu, Shichong
    DRUG DESIGN DEVELOPMENT AND THERAPY, 2019, 13 : 4239 - 4246
  • [34] Efficacy of Gefitinib Combined with 125I Radioactive Particles in the Treatment of Transplanted Lung Cancer Tumors in Nude Mice
    Li, Chaojie
    Yao, Linyan
    Gong, Ju
    Pang, Haopeng
    Shan, Qungang
    Wang, Ziyin
    Lu, Jian
    Wang, Zhongmin
    CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY, 2020, 43 (09) : 1364 - 1370
  • [35] The mechanism of trans-δ-viniferin inhibiting the proliferation of lung cancer cells A549 by targeting the mitochondria
    Yin, Ruochun
    Zhang, Yiling
    Su, Liping
    Chen, Dongdong
    Lou, Shidi
    Luo, Xuecai
    Wang, Lin
    Tang, Rupei
    Zhang, Liang
    Tian, Xiaohe
    FRONTIERS IN PHARMACOLOGY, 2023, 14
  • [36] Mechanism of curcumin analog MHMD-induced cell death in A549 lung cancer cells
    Zhou, G-Z.
    Cao, F-K.
    Chang, J-M.
    Sun, G-C.
    Chen, X-B.
    EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2014, 18 (20) : 3134 - 3138
  • [37] The apoptotic mechanism of chloramquinone in human non-small cell lung cancer A549 cells
    Kim, S
    Lim, J
    LUNG CANCER, 2005, 49 : S131 - S131
  • [38] Analysis of Polyphyllin II alters microRNA expression profile in lung cancer A549 cells
    Peng, Weidong
    Huang, Huimin
    Liu, Jingjian
    Zhang, Binqiang
    Wu, Lun
    Liu, Zhongzhi
    Ran, Fengying
    MCB Molecular and Cellular Biomechanics, 2024, 21 (01):
  • [39] Application value of the treatment of breast cancer bone metastases with radioactive seed 125I implantation under CT-guidance
    Haiwen Li
    Maobo Wang
    Zhenhua Zhu
    Yingqiang Lu
    BMC Medical Imaging, 22
  • [40] Application value of the treatment of breast cancer bone metastases with radioactive seed 125I implantation under CT-guidance
    Li, Haiwen
    Wang, Maobo
    Zhu, Zhenhua
    Lu, Yingqiang
    BMC MEDICAL IMAGING, 2022, 22 (01)
12345