Comparative transcriptome analysis providing inhibitory mechanism of lung cancer A549 cells by radioactive 125I seed

被引：0

作者：

Fang Liu

Jie Bao

Jinwu Chen

Wencheng Song

机构：

[1] Chinese Academy of Sciences,Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health & Medical Technology, Hefei Institutes of Physical Science

[2] Anhui University,School of Life Science

[3] Hefei Cancer Hospital,Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions and School for Radiological and Interdisciplinary Sciences

[4] Chinese Academy of Sciences,undefined

[5] Hefei Normal University,undefined

[6] Soochow University,undefined

来源：

Journal of Radioanalytical and Nuclear Chemistry | 2021年 / 330卷

关键词：

I seed; Transcriptome; Inhibitory mechanism; A549 cells;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

In this study, A549 cells treated by radioactive 125I seed were sequenced using Illumina HiSeq PE150, and then the transcriptome was analyzed using bioinformatics methods. Gene ontology classification analysis showed that differentially expressed genes (DEGs) belonged to 10 categories, and low-dose group, medium-dose group and high-dose group 125I treatment obtained 440 DEGs, 4275 DEGs and 2850 DEGs, respectively. Additionally, DEGs were involved in tumor-related pathways, endoplasmic reticulum protein processing and cell cycle pathways. Therefore, radioactive 125I seed can significantly inhibit the growth of lung cancer, which provide a theoretical basis for the clinical 125I seed to effectively treat lung cancer.

引用

页码：821 / 831

页数：10

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