Comparison of Generic Hydrochlorothiazide Formulations by Means of TG and DSC Coupled to a Photovisual System

被引：0
|
作者：
R. O. Macêdo
T. G. do Nascimento
J. W. E. Veras
机构：
[1] Universidade Federal da Paraíba,Laboratório de Tecnologia Farmacêutica
来源：
Journal of Thermal Analysis and Calorimetry | 2001年 / 64卷
关键词：
formulations; hydrochlorothiazide; thermal analysis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The compatibilities and stabilities of some binary mixtures and generic hydrochlorothiazide formulations were studied by using TG, DSC and a DSC-photovisual system. The kinetic parameters were determined via the Arrhenius equations. Tablet B presented higher compatibility and thermal stability than those of tablets A and C. The photovisual system demonstrated that the decomposition of tablet A occurs before the melting point, due to the Maillard reaction between the hydrochlorothiazide and lactose present in the formulation. The behaviour and rate constants of binary mixtures suggest that lactose can be substituted for microcrystalline cellulose, MC(101), in tablet A. The DSC and TG data revealed different characteristics of compatibility and stability in generic formulations from different manufacturers.
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页码：757 / 763
页数：6
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