Thermal Characterization of Lapachol by Means of TG and DSC Coupled to a Photovisual System

被引：0
|
作者：
R. O. Macêdo
T. G. do Nascimento
机构：
[1] Universidade Federal da Paraíba,Laboratório de Tecnologia Farmacêutica
来源：
Journal of Thermal Analysis and Calorimetry | 2001年 / 64卷
关键词：
DSC-photovisual system; lapachol; TG;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Thermal characterization is proposed as analytical methodology for the purity assay of lapachol, and for determination of the quality parameters of capsules containing this molecule. The TG data revealed that lapachol is more stable in the presence of adjuvants, showing the good quality of the formulation. The kinetic parameters obtained were lower for lapachol drug than for the formulated lapachol. The DSC data demonstrated good compatibility between lapachol drug and the adjuvant in the formulated lapachol, and did not reveal impurities such as secondary products of the isolation and recrystallization processes. The data were confirmed by the DSC-photovisual findings.
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页码：751 / 756
页数：5
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