DCE-MRI biomarkers in the clinical evaluation of antiangiogenic and vascular disrupting agents

被引：0
|
作者：
J P B O'Connor
A Jackson
G J M Parker
G C Jayson
机构：
[1] Imaging Science and Biomedical Engineering,Cancer Research UK Department of Medical Oncology
[2] University of Manchester,undefined
[3] Christie Hospital,undefined
来源：
British Journal of Cancer | 2007年 / 96卷
关键词：
angiogenesis inhibitors; biomarkers; clinical trials; dynamic contrast-enhanced magnetic resonance imaging; image analysis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is now frequently used in early clinical trial assessment of antiangiogenic and vascular disrupting compounds. Evidence of drug efficacy and dose-dependent response has been demonstrated with some angiogenesis inhibitors. This review highlights the critical issues that influence T1-weighted DCE-MRI data acquisition and analysis, identifies important areas for future development and reviews the clinical trial findings to date.
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页码：189 / 195
页数：6
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