Elevated male European and female African contributions to the genomes of African American individuals

被引:0
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作者
Joanne M. Lind
Holli B. Hutcheson-Dilks
Scott M. Williams
Jason H. Moore
Myron Essex
Eduardo Ruiz-Pesini
Douglas C. Wallace
Sarah A. Tishkoff
Stephen J. O’Brien
Michael W. Smith
机构
[1] Laboratory of Genomic Diversity,Department of Molecular Physiology and Biophysics, Center for Human Genetics Research, and Division of Cardiovascular Medicine, Department of Medicine
[2] NCI-Frederick,Computational Genetics Laboratory, Department of Genetics, Department of Community and Family Medicine, Norris Cotton Cancer Center
[3] Vanderbilt University,Harvard AIDS Institute and Department of Immunology and Infectious Diseases
[4] Dartmouth Medical School,Center for Molecular and Mitochondrial Medicine and Genetics
[5] Harvard School of Public Health,Department of Biology
[6] University of California,Basic Research Program
[7] University of Maryland,Agnes Ginges Centre for Molecular Cardiology
[8] SAIC-Frederick,undefined
[9] Inc.,undefined
[10] NCI-Frederick,undefined
[11] Centenary Institute,undefined
[12] National Cancer Institute at Frederick,undefined
[13] Bldg 560,undefined
[14] Rm 21-74,undefined
[15] SAIC-Frederick,undefined
来源
Human Genetics | 2007年 / 120卷
关键词
Sex-biased gene flow; Admixture;
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摘要
The differential relative contribution of males and females from Africa and Europe to individual African American genomes is relevant to mapping genes utilizing admixture analysis. The assessment of ancestral population contributions to the four types of genomic DNA (autosomes, X and Y chromosomes, and mitochondrial) with their differing modes of inheritance is most easily addressed in males. A thorough evaluation of 93 African American males for 2,018 autosomal single nucleotide polymorphic (SNP) markers, 121 X chromosome SNPs, 10 Y chromosome haplogroups specified by SNPs, and six haplogroup defining mtDNA SNPs is presented. A distinct lack of correlation observed between the X chromosome and the autosomal admixture fractions supports separate treatment of these chromosomes in admixture-based gene mapping applications. The European genetic contributions were highest (and African lowest) for the Y chromosome (28.46%), followed by the autosomes (19.99%), then the X chromosome (12.11%), and the mtDNA (8.51%). The relative order of admixture fractions in the genomic compartments validates previous studies that suggested sex-biased gene flow with elevated European male and African female contributions. There is a threefold higher European male contribution compared with European females (Y chromosome vs. mtDNA) to the genomes of African American individuals meaning that admixture-based gene discovery will have the most power for the autosomes and will be more limited for X chromosome analysis.
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页码:713 / 722
页数:9
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