Time-of-day dependent pharmacodynamic and pharmacokinetic profiles of caffeine in rats

被引:0
|
作者
Anne-Laure Pelissier-Alicot
Elisabeth Schreiber-Deturmeny
Nicolas Simon
Manon Gantenbein
Bernard Bruguerolle
机构
[1] Laboratoire de Pharmacologie Médicale et Clinique,
[2] Faculté de Médecine,undefined
[3] Université de la Méditerranée,undefined
[4] 27 Bd. Jean Moulin,undefined
[5] 13385 Marseille Cedex 5,undefined
[6] France,undefined
关键词
Daily rhythms Telemetry Chronopharmacodynamics Chronopharmacokinetics Rats;
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中图分类号
学科分类号
摘要
This study aims to investigate the effects of caffeine on the daily rhythms of heart rate (HR), body temperature (BT) and locomotor activity (LA) in rats in relation to time-of-day of administration, as well as their possible mechanisms, particularly related to caffeine pharmacokinetics.
引用
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页码:318 / 325
页数:7
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