Research priorities for therapeutic plasma exchange in critically ill patients

被引:0
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作者
Sascha David
Lene Russell
Pedro Castro
Andry van de Louw
Lara Zafrani
Tasneem Pirani
Nathan D. Nielsen
Eric Mariotte
Bruno L. Ferreyro
Jan T. Kielstein
Luca Montini
Anne C. Brignier
Matthias Kochanek
Joan Cid
Chiara Robba
Ignacio Martin-Loeches
Marlies Ostermann
Nicole P. Juffermans
机构
[1] University Hospital Zurich,Institute of Intensive Care Medicine
[2] Hannover Medical School,Department of Nephrology and Hypertension
[3] Copenhagen University Hospital Gentofte,Department of Intensive Care
[4] University of Copenhagen,Department of Clinical Medicine
[5] Hospital Clínic of Barcelona,Medical Intensive Care Unit
[6] IDIBAPS,Medical Intensive Care Unit
[7] University of Barcelona,Medical Intensive Care Unit
[8] Penn State Health Hershey Medical Center,Division of Pulmonary, Critical Care and Sleep Medicine & Section of Transfusion Medicine and Therapeutic Pathology
[9] Saint-Louis Hospital,Department of Medicine
[10] AP-HP,Medical Clinic V, Nephrology, Rheumatology, Blood Purification
[11] University of Paris Cité,Department of Intensive Care Medicine and Anesthesiology
[12] King’s College Hospital,Apheresis Unit
[13] General and Liver Intensive Care,Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO)
[14] University of New Mexico School of Medicine,Apheresis and Cellular Therapy Unit, Department of Hemotherapy and Hemostasis
[15] Sinai Health System and University Health Network,Dipartimento di Scienze Chirurgiche Diagnostiche ed Integrate
[16] Academic Teaching Hospital Braunschweig,Department of Intensive Care Medicine, Multidisciplinary Intensive Care Research Organization (MICRO)
[17] “Fondazione Policlinico Universitario Agostino Gemelli IRCCS” Università Cattolica del Sacro Cuore,Department of Clinical Medicine, School of Medicine
[18] Saint-Louis Hospital,Department of Intensive Care
[19] AP-HP,Department of Intensive Care
[20] University of Paris Cite,Laboratory of Translational Intensive Care
[21] University of Cologne,undefined
[22] ICMHO,undefined
[23] Clínic Barcelona,undefined
[24] IDIBAPS,undefined
[25] University of Barcelona,undefined
[26] IRCCS per Oncologia e Neuroscienze,undefined
[27] Universita’ di Genova,undefined
[28] St. James’s Hospital,undefined
[29] Trinity College Dublin,undefined
[30] Institut D’Investigacions Biomediques August Pi i Sunyer (IDIBAPS),undefined
[31] Hospital Clinic,undefined
[32] Universidad de Barcelona,undefined
[33] Guy’s & St Thomas’ Hospital,undefined
[34] King’s College London,undefined
[35] OLVG Hospital,undefined
[36] Erasmus MC,undefined
来源
Intensive Care Medicine Experimental | / 11卷
关键词
Knowledge; Gaps; Plasmapheresis; Expert panel; Apheresis; Research; Plasma exchange; Research;
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摘要
Therapeutic plasma exchange (TPE) is a therapeutic intervention that separates plasma from blood cells to remove pathological factors or to replenish deficient factors. The use of TPE is increasing over the last decades. However, despite a good theoretical rationale and biological plausibility for TPE as a therapy for numerous diseases or syndromes associated with critical illness, TPE in the intensive care unit (ICU) setting has not been studied extensively. A group of eighteen experts around the globe from different clinical backgrounds used a modified Delphi method to phrase key research questions related to “TPE in the critically ill patient”. These questions focused on: (1) the pathophysiological role of the removal and replacement process, (2) optimal timing of treatment, (3) dosing and treatment regimes, (4) risk–benefit assumptions and (5) novel indications in need of exploration. For all five topics, the current understanding as well as gaps in knowledge and future directions were assessed. The content should stimulate future research in the field and novel clinical applications.
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