In vitro and in vivo characterization of MPEP, an allosteric modulator of the metabotropic glutamate receptor subtype 5: Review article

被引：0

作者：

R. Kuhn

A. Pagano

N. Stoehr

I. Vranesic

P. J. Flor

K. Lingenhöhl

W. Spooren

C. Gentsch

A. Vassout

A. Pilc

F. Gasparini

机构：

[1] Nervous System Research,

[2] Novartis,undefined

[3] Pharma AG,undefined

[4] Basel,undefined

[5] Switzerland,undefined

[6] Institute of Pharmacology,undefined

[7] Polish Academy of Science,undefined

[8] Krakow,undefined

[9] Poland,undefined

来源：

Amino Acids | 2002年 / 23卷

关键词：

Keywords: Group I metabotropic glutamate receptors; MPEP; SIB-1757; Anxiety; Pain;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

There is a need to identify subtype-specific ligands for mGlu receptors to elucidate the potential of these receptors for the treatment of nervous system disorders. To date, most mGlu receptor antagonists are amino acid-like compounds acting as competitive antagonists at the glutamate binding site located in the large extracellular N-terminal domain.

引用

页码：207 / 211

页数：4

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