In vitro and in vivo characterization of MPEP, an allosteric modulator of the metabotropic glutamate receptor subtype 5: Review article

被引：0
|
作者：
R. Kuhn
A. Pagano
N. Stoehr
I. Vranesic
P. J. Flor
K. Lingenhöhl
W. Spooren
C. Gentsch
A. Vassout
A. Pilc
F. Gasparini
机构：
[1]  Nervous System Research,
[2] Novartis,undefined
[3] Pharma AG,undefined
[4] Basel,undefined
[5] Switzerland,undefined
[6]  Institute of Pharmacology,undefined
[7] Polish Academy of Science,undefined
[8] Krakow,undefined
[9] Poland,undefined
来源：
Amino Acids | 2002年 / 23卷
关键词：
Keywords: Group I metabotropic glutamate receptors; MPEP; SIB-1757; Anxiety; Pain;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
 There is a need to identify subtype-specific ligands for mGlu receptors to elucidate the potential of these receptors for the treatment of nervous system disorders. To date, most mGlu receptor antagonists are amino acid-like compounds acting as competitive antagonists at the glutamate binding site located in the large extracellular N-terminal domain.
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页码：207 / 211
页数：4
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