Research on self-compassion in adults and adolescents has consistently shown positive associations of self-compassion to mindfulness, psychological and physical well-being, self-esteem, and compassion towards others. Yet, self-compassion in children has not been examined. The present study was conducted to explore the reliability and validity of the Self-Compassion Scale for Children (SCS-C). A sample of 406 children, ages 8 to 12, completed the SCS-C and measures of mindfulness, self-concept, well-being and psychological adjustment, empathic-related responding, and prosocial goals. Results indicated a two-factor structure for the SCS-C with negatively-worded items and positively-worded items forming two discrete subscales, each with acceptable internal consistency (Cronbach’s alpha = .81–.83). Children’s scores on the positive and negative self-compassion subscales were significantly related to most of the self-reported measures in the expected directions. These findings provide insight into the factor structure of the SCS-C and are consistent with previous research on the Self-Compassion Scale with adult and adolescent populations. Limitations and future directions are discussed with regard to the two-factor structure of the SCS-C and its relevance for research and applications.