Baseline JAK-STAT signaling maintains immune cell homeostasis

被引：0
|
作者：
Bock, Christoph [1 ,2 ]
Decker, Thomas [3 ]
Mueller, Mathias [4 ]
机构：
[1] CeMM, Vienna, Austria
[2] Med Univ Vienna, Vienna, Austria
[3] Univ Vienna, Max Perutz Labs, Vienna, Austria
[4] Vetmeduni Vienna, Vienna, Austria
来源：
NATURE IMMUNOLOGY | 2024年 / 25卷 / 05期
关键词：
D O I：
10.1038/s41590-024-01805-0
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Homeostatic immune cells remain perpetually vigilant against pathogens. We found that baseline JAK-STAT signaling supports the characteristic transcriptional and epigenetic state of homeostatic T cells and macrophages in mice. JAK-STAT signaling under homeostatic conditions was driven by signals from healthy tissue and did not require external immune stimuli.
引用
收藏
页码：741 / 742
页数：42
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