Mapping the 3D orientation of piconewton integrin traction forces

被引:0
|
作者
Joshua M Brockman
Aaron T Blanchard
Victor Pui-Yan
Wallace D Derricotte
Yun Zhang
Meredith E Fay
Wilbur A Lam
Francesco A Evangelista
Alexa L Mattheyses
Khalid Salaita
机构
[1] Georgia Institute of Technology and Emory University,Wallace H. Coulter Department of Biomedical Engineering
[2] Emory University,Department of Chemistry
[3] Emory University School of Medicine,Department of Cell Biology
[4] Morehouse College,Department of Chemistry
[5] University of Alabama at Birmingham,Department of Cell, Developmental, and Integrative Biology
来源
Nature Methods | 2018年 / 15卷
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摘要
Molecular force microscopy employs a combination of fluorescence polarization microscopy and molecular tension sensors to determine the orientation of cellular forces. The technology is demonstrated for integrin-mediated forces in platelets and fibroblasts.
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页码:115 / 118
页数:3
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