Cardiovascular implications of HIV-associated dyslipidemic lipodystrophy

被引：14
|
作者：
Sekhar R.V. [1 ]
Jahoor F. [1 ]
Pownall H.J. [1 ]
Ballantyne C.M. [1 ]
Balasubramanyam A. [1 ]
机构：
[1] Division of Endocrinology, Baylor College of Medicine, Houston, TX 77030, One Baylor Plaza
来源：
Current Atherosclerosis Reports | 2004年 / 6卷 / 3期
基金：
美国国家卫生研究院;
关键词：
Insulin Resistance; Cholesteryl Ester Transfer Protein; Lipodystrophy; Postprandial Lipemia; Intramyocellular Lipid;
D O I：
10.1007/s11883-004-0029-2
中图分类号：
学科分类号：
摘要：
The emergence of a new metabolic syndrome in patients with HIV infection, termed "HIV-associated dyslipidemic lipodystrophy" (HADL), is characterized by central fat redistribution, severe dyslipidemia, and insulin resistance and predisposes to an increased risk of cardiovascular disease. The factors promoting the development of cardiovascular disease in this condition are not well understood and may involve contributions from antiretroviral drugs and components of the HIV virus, as well as inflammatory cytokines, leading to accelerated lipolysis, dyslipidemia, lipotoxic insulin resistance, and vascular inflammation. In this article, we review HADL in terms of metabolic, molecular, and cytokine derangements leading to cardiovascular disease. Copyright © 2004 by Current Science Inc.
引用
收藏
页码：173 / 179
页数：6
相关论文
共 50 条
  • [31] Excisional lipectomy versus liposuction in HIV-associated lipodystrophy
    Barton, Natalie
    Moore, Ryan
    Prasad, Karthik
    Evans, Gregory
    [J]. ARCHIVES OF PLASTIC SURGERY-APS, 2021, 48 (06): : 685 - 690
  • [32] Obstructive sleep apnea due to HIV-associated lipodystrophy
    Schulz, R
    Lohmeyer, J
    Seeger, W
    [J]. CLINICAL INFECTIOUS DISEASES, 2003, 37 (10) : 1398 - 1399
  • [33] HIV-associated lipodystrophy: Pathogenesis, prognosis, treatment, and controversies
    Koutkia, P
    Grinspoon, S
    [J]. ANNUAL REVIEW OF MEDICINE, 2004, 55 : 303 - 317
  • [34] What Does the Term "HIV-Associated Lipodystrophy" Mean?
    Marcason, Wendy
    [J]. JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION, 2009, 109 (02) : 364 - 364
  • [35] Adipogenic gene variants in patients with HIV-associated lipodystrophy
    Pushpakom, S.
    Owen, A.
    Vilar, J.
    Back, D.
    Pirmohamed, M.
    [J]. HIV MEDICINE, 2009, 10 : 1 - 1
  • [36] ROLE OF NEDD8 IN HIV-ASSOCIATED LIPODYSTROPHY
    Esposito, V.
    Gargiulo, M.
    Parrella, R.
    Sangiovanni, V.
    Viglietti, R.
    Fortunato, V.
    Onofrio, M.
    Chirianni, A.
    [J]. INFECTION, 2009, 37 : 83 - 83
  • [37] Clinical perspectives on HIV-associated lipodystrophy syndrome: an update
    Shevitz, A
    Wanke, CA
    Falutz, J
    Kotler, DP
    [J]. AIDS, 2001, 15 (15) : 1917 - 1930
  • [38] Clinical assessment of HIV-associated lipodystrophy in an ambulatory population
    Lichtenstein, KA
    Ward, DJ
    Moorman, AC
    Delaney, KM
    Young, B
    Palella, FJ
    Rhodes, PH
    Wood, KC
    Holmberg, SD
    [J]. AIDS, 2001, 15 (11) : 1389 - 1398
  • [39] Adipogenic gene variants in patients with HIV-associated lipodystrophy
    Pushpakom, Sudeep P.
    Owen, Andrew
    Vilar, F. Javier
    Castro, Hannah
    Dunn, David T.
    Back, David J.
    Pirmohamed, Munir
    [J]. PHARMACOGENETICS AND GENOMICS, 2011, 21 (02): : 76 - 83
  • [40] HIV-associated lipodystrophy: a review from a Brazilian perspective
    Alves, Marcelle D.
    Brites, Carlos
    Sprinz, Eduardo
    [J]. THERAPEUTICS AND CLINICAL RISK MANAGEMENT, 2014, 10 : 559 - 566
12345