Effects of Prulifloxacin on Cardiac Repolarization in Healthy SubjectsA Randomized, Crossover, Double-Blind versus Placebo, Moxifloxacin-Controlled Study

被引：0

作者：

Maria Teresa Rosignoli

Giorgio Di Loreto

Paolo Dionisio

机构：

[1] ACRAF SpA,Headquarters Medical Department, Angelini Pharmaceuticals

[2] ACRAF SpA,Angelini Pharmaceuticals

来源：

Clinical Drug Investigation | 2010年 / 30卷

关键词：

Moxifloxacin; Ranolazine; Sparfloxacin; Grepafloxacin; Gemifloxacin;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Background and Objective: Prulifloxacin, a broad-spectrum fluoroquinolone, is quantitatively transformed after oral administration into ulifloxacin, the active metabolite. On the basis of preclinical data suggesting that prulifloxacin is not likely to prolong the QT interval, a trial to assess the potential effects of prulifloxacin on QT and corrected QT (QTc) interval in humans was performed.

引用

页码：5 / 14

页数：9

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