Effects of Prulifloxacin on Cardiac Repolarization in Healthy SubjectsA Randomized, Crossover, Double-Blind versus Placebo, Moxifloxacin-Controlled Study

被引：0
|
作者：
Maria Teresa Rosignoli
Giorgio Di Loreto
Paolo Dionisio
机构：
[1] ACRAF SpA,Headquarters Medical Department, Angelini Pharmaceuticals
[2] ACRAF SpA,Angelini Pharmaceuticals
来源：
Clinical Drug Investigation | 2010年 / 30卷
关键词：
Moxifloxacin; Ranolazine; Sparfloxacin; Grepafloxacin; Gemifloxacin;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Background and Objective: Prulifloxacin, a broad-spectrum fluoroquinolone, is quantitatively transformed after oral administration into ulifloxacin, the active metabolite. On the basis of preclinical data suggesting that prulifloxacin is not likely to prolong the QT interval, a trial to assess the potential effects of prulifloxacin on QT and corrected QT (QTc) interval in humans was performed.
引用
收藏
页码：5 / 14
页数：9
相关论文
共 50 条
  • [1] Effects of Prulifloxacin on Cardiac Repolarization in Healthy Subjects A Randomized, Crossover, Double-Blind versus Placebo, Moxifloxacin-Controlled Study
    Rosignoli, Maria Teresa
    Di Loreto, Giorgio
    Dionisio, Paolo
    CLINICAL DRUG INVESTIGATION, 2010, 30 (01) : 5 - 14
  • [2] A RANDOMIZED, DOUBLE-BLIND, PLACEBO-AND MOXIFLOXACIN-CONTROLLED, 4 PERIOD CROSSOVER TRIAL TO EVALUATE THE EFFECT OF ESLICARBAZEPINE ACETATE ON CARDIAC REPOLARIZATION IN HEALTHY SUBJECTS
    Almeida, L.
    Nunes, T.
    Gutierrez, M.
    Litwin, J.
    Soares-Da-Silva, P.
    EPILEPSIA, 2009, 50 : 104 - 104
  • [3] A randomized, double-blind, placebo- and positive-controlled crossover study of the effects of durlobactam on cardiac repolarization in healthy subjects
    O'Donnell, John
    Maloney, Kathleen
    Steidler, Melissa
    Morrison, Royce
    Isaacs, Robin
    CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 2021, 14 (04): : 1423 - 1430
  • [4] A single-dose placebo- and moxifloxacin-controlled study of the effects of temsirolimus on cardiac repolarization in healthy adults
    Boni, Joseph P.
    Leister, Cathie
    Hug, Bruce
    Burns, Jaime
    Sonnichsen, Daryl
    CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2012, 69 (06) : 1433 - 1442
  • [5] A single-dose placebo- and moxifloxacin-controlled study of the effects of temsirolimus on cardiac repolarization in healthy adults
    Joseph P. Boni
    Cathie Leister
    Bruce Hug
    Jaime Burns
    Daryl Sonnichsen
    Cancer Chemotherapy and Pharmacology, 2012, 69 : 1433 - 1442
  • [6] Effects of the Selective α1A-Adrenoceptor Antagonist Silodosin on ECGs of Healthy Men in a Randomized, Double-Blind, Placebo- and Moxifloxacin-Controlled Study
    Morganroth, J.
    Lepor, H.
    Hill, L. A.
    Volinn, W.
    Hoel, G.
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2010, 87 (05) : 609 - 613
  • [7] A SINGLE DOSE, CROSSOVER, PLACEBO- AND MOXIFLOXACIN-CONTROLLED STUDY TO ASSESS THE EFFECTS OF BOSUTINIB (SKI-606) ON CARDIAC REPOLARIZATION IN HEALTHY ADULT SUBJECTS
    Abbas, R.
    Hug, B.
    Leister, C.
    Burns, J.
    Sonnichsen, D.
    HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2010, 95 : 353 - 353
  • [8] A Single-Dose, Crossover, Placebo- and Moxifloxacin-Controlled Study to Assess the Effects of Neratinib (HKI-272) on Cardiac Repolarization in Healthy Adult Subjects
    Hug, Bruce
    Abbas, Richat
    Leister, Cathie
    Burns, Jaime
    Sonnichsen, Daryl
    CLINICAL CANCER RESEARCH, 2010, 16 (15) : 4016 - 4023
  • [9] Cardiac Repolarization With Gabapentin Enacarbil in a Randomized, Double-Blind, Placebo- and Active-Controlled, Crossover Thorough QT/QTc Study in Healthy Adults
    Davy, Maria
    Upward, James
    Arumugham, Thangam
    Twomey, Colleen
    Chen, Chao
    Stier, Brendt
    CLINICAL THERAPEUTICS, 2013, 35 (12) : 1964 - 1974
  • [10] A single-dose, crossover, placebo- and moxifloxacin-controlled study to assess the effects of neratinib (HKI-272) on cardiac repolarization in healthy adult subjects.
    Abbas, R.
    Hug, B. A.
    Leister, C.
    Burns, J.
    Sonnichsen, D.
    JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (15)
12345