Development of a tissue-engineered skin model with epidermal, dermal and hypodermal components

被引：0

作者：

V. L. Workman

A-V. Giblin

N. H. Green

S. MacNeil

V. Hearnden

机构：

[1] University of Sheffield,Department of Materials Science and Engineering

[2] Sheffield Teaching Hospitals NHS Foundation Trust,Department of Plastic Surgery

来源：

In vitro models | 2023年 / 2卷 / 6期

关键词：

Tissue engineering; Skin; Adipose; Hypodermis; Cytokeratin; Rete ridges; Dermal-epidermal junction;

D O I：

10.1007/s44164-023-00058-9

中图分类号：

学科分类号：

摘要：

Tissue-engineered models of skin have evolved over the past 50 years, have successfully been translated to clinical use and continue to be improved using new technologies. However, very few of these constructs incorporate a hypodermal component. The hypodermis is critical to skin homeostasis, skin function and many skin diseases, but our understanding of the hypodermis is limited in comparison to our knowledge of the epidermis and dermis, in part due to a lack of suitable in vitro models.

引用

页码：297 / 306

页数：9

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