Benzo[a]pyrene Induction of Cytochrome P450 1A1/1A2 in the Lymph Nodes of Rats

被引：0
|
作者：
Yu. I. Borodin
A. F. Safina
I. V. Maiborodin
A. Yu. Grishanova
机构：
[1] Institute of Clinical and Experimental Lymphology,Siberian Division of Russian Academy of Medical Sciences
[2] Institute of Molecular Biology and Biophysics,Siberian Division of Russian Academy of Medical Sciences
来源：
Bulletin of Experimental Biology and Medicine | 2003年 / 136卷
关键词：
cytochrome P450; benzo[a]pyrene; lymph nodes; macrophages; endotheliocytes;
D O I：
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中图分类号：
学科分类号：
摘要：
Studies of mesenteric lymph nodes of rats by indirect immunoperoxidase method using monoclonal antibodies to cytochrome P450 1A1/1A2 after oral dose of benzo[a]pyrene showed the presence of these cytochrome forms in monocytes, macrophages, reticular and litoral cells, cell detritus, and liquid contents of the paracortical zone and medullary substance sinuses. Oxidation of various exo- and endogenous toxins in the lymph nodes was revealed.
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页码：611 / 614
页数：3
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