Benzo[a]pyrene induction of cytochrome P450 1A1/1A2 in the lymph nodes of rats

被引：3
|
作者：
Borodin, YI [1 ]
Safina, AF
Maiborodin, IV
Grishanova, AY
机构：
[1] Russian Acad Med Sci, Siberian Div, Inst Clin & Expt Lymphol, Novosibirsk, Russia
[2] Russian Acad Med Sci, Siberian Div, Inst Mol Biol & Biophys, Novosibirsk, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2003年 / 136卷 / 06期
关键词：
cytochrome P450; benzo[a]pyrene; lymph nodes; macrophages; endotheliocytes;
D O I：
10.1023/B:BEBM.0000020218.48306.e0
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Studies of mesenteric lymph nodes of rats by indirect immunoperoxidase method using monoclonal antibodies to cytochrome P450 1A1/1A2 after oral dose of benzo[a]pyrene showed the presence of these cytochrome forms in monocytes, macrophages, reticular and litoral cells, cell detritus, and liquid contents of the paracortical zone and medullary substance sinuses. Oxidation of various exo- and endogenous toxins in the lymph nodes was revealed.
引用
收藏
页码：611 / 614
页数：4
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