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mRNA structures control the post-transcriptional gene regulation

被引：0
|
作者：
Lichtenthaeler C. [1 ]
Oberstrass L. [1 ]
Weigand J.E. [1 ]
机构：
[1] Fachbereich Biologie, Technische Universität Darmstadt, Schnittspahnstraße 10, Darmstadt
来源：
BIOspektrum | 2021年 / 27卷 / 4期
关键词：
D O I：
10.1007/s12268-021-1600-x
中图分类号：
学科分类号：
摘要：
Posttranscriptional regulation at mRNA level is defined not only by sequence, but also by the structure of the mRNA. Structures in the untranslated regions control stability, translation and localization of an mRNA. Evolutionary conservation can be used to identify such regulatory active structures in mRNAs. For example, constitutive decay element (CDE) stem-loops are recognized by Roquin proteins in an exclusively shape-specific manner. Strikingly, some CDEs can serve a dual function in gene repression depending on their folding status. © 2021, Die Autoren.
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页码：351 / 354
页数：3
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