Clinical Pharmacology and Therapeutic Potential of Monoclonal Antibody Treatment in Rheumatoid Arthritis

被引：0
|
作者：
Ernest H. S. Choy
机构：
[1] Guy’s and King’s College Hospitals,Rheumatology Unit
[2] Guy’s Hospital,Rheumatology Unit, 5th Floor, Thomas Guy House
来源：
Drugs & Aging | 1998年 / 12卷
关键词：
Rheumatoid Arthritis; Adis International Limited; Synovial Fluid; Rheumatol; Synovial Joint;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Many monoclonal antibodies (mAb) have been tested in rheumatoid arthritis (RA). Murine antibodies were antigenic and caused human antimouse responses in the recipients. As a result, re-treatments were less effective and were associated with an increased risk of anaphylaxis. Advances in biotechnology have allowed us to develop chimaeric and humanised mAb that are less antigenic than their murine equivalents.
引用
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页码：139 / 148
页数：9
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