Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes

被引：0

作者：

Tony Jourdan

Grzegorz Godlewski

Resat Cinar

Adeline Bertola

Gergő Szanda

Jie Liu

Joseph Tam

Tiffany Han

Bani Mukhopadhyay

Monica C Skarulis

Cynthia Ju

Myriam Aouadi

Michael P Czech

George Kunos

机构：

[1] Laboratory of Physiologic Studies,

[2] National Institute on Alcohol Abuse and Alcoholism,undefined

[3] US National Institutes of Health,undefined

[4] Laboratory of Liver Diseases,undefined

[5] National Institute on Alcohol Abuse and Alcoholism,undefined

[6] US National Institutes of Health,undefined

[7] Diabetes,undefined

[8] Endocrinology and Obesity Branch,undefined

[9] National Institute of Diabetes and Digestive and Kidney Diseases,undefined

[10] US National Institutes of Health,undefined

[11] Skaggs School of Pharmacy and Pharmaceutical Sciences,undefined

[12] University of Colorado Anschutz Medical Campus,undefined

[13] Program in Molecular Medicine,undefined

[14] University of Massachusetts Medical School,undefined

来源：

Nature Medicine | 2013年 / 19卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

George Kunos and his colleagues show in a rat model that endocannabinoid activation of the Nlrp3 inflammasome in macrophages results in death of pancreatic beta cells, and thus development of type 2 diabetes mellitus. These results suggest that preventing this process might be a therapeutic option for diabetes in the clinic.

引用

页码：1132 / 1140

页数：8

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