Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes

被引:0
|
作者
Tony Jourdan
Grzegorz Godlewski
Resat Cinar
Adeline Bertola
Gergő Szanda
Jie Liu
Joseph Tam
Tiffany Han
Bani Mukhopadhyay
Monica C Skarulis
Cynthia Ju
Myriam Aouadi
Michael P Czech
George Kunos
机构
[1] Laboratory of Physiologic Studies,
[2] National Institute on Alcohol Abuse and Alcoholism,undefined
[3] US National Institutes of Health,undefined
[4] Laboratory of Liver Diseases,undefined
[5] National Institute on Alcohol Abuse and Alcoholism,undefined
[6] US National Institutes of Health,undefined
[7] Diabetes,undefined
[8] Endocrinology and Obesity Branch,undefined
[9] National Institute of Diabetes and Digestive and Kidney Diseases,undefined
[10] US National Institutes of Health,undefined
[11] Skaggs School of Pharmacy and Pharmaceutical Sciences,undefined
[12] University of Colorado Anschutz Medical Campus,undefined
[13] Program in Molecular Medicine,undefined
[14] University of Massachusetts Medical School,undefined
来源
Nature Medicine | 2013年 / 19卷
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学科分类号
摘要
George Kunos and his colleagues show in a rat model that endocannabinoid activation of the Nlrp3 inflammasome in macrophages results in death of pancreatic beta cells, and thus development of type 2 diabetes mellitus. These results suggest that preventing this process might be a therapeutic option for diabetes in the clinic.
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页码:1132 / 1140
页数:8
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