Camels’ biological fluids contained nanobodies: promising avenue in cancer therapy

被引:0
|
作者
Nouf S. Al-Numair
Abdulrahman Theyab
Faisal Alzahrani
Anwar M. Shams
Ibrahim O. Al-Anazi
Atif Abdulwahab A. Oyouni
Osama M. Al-Amer
Charalampos Mavromatis
Islam M. Saadeldin
Wed A. Abdali
Yousef M. Hawsawi
机构
[1] King Faisal Specialist Hospital & Research Center,Center of Genomic Medicine
[2] Alfaisal University,College of Medicine
[3] Security Forces Hospital,Department of Laboratory & Blood Bank
[4] Al-Faisal University,College of Medicine
[5] King Fahad Medical Center,Department of Biochemistry, Faculty of Science, Embryonic Stem Cells Unit
[6] King Abdulaziz University,Centre of Artificial Intelligence in Precision Medicines (CAIPM)
[7] King Abdulaziz University,Department of Pharmacology, College of Medicine
[8] Taif University,Department of Biology, Faculty of Sciences
[9] The National Center for Genomic Technology,Genome and Biotechnology Unit, Faculty of Sciences
[10] King Abdulaziz City for Science and Technology,Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences
[11] University of Tabuk,Department of Biological Sciences, Faculty of Science and Arts (Rabigh Campus)
[12] University of Tabuk,Research Institute of Veterinary Medicine
[13] University of Tabuk,Research Center
[14] King Abdulaziz University,undefined
[15] Chungam National University,undefined
[16] King Faisal Specialist Hospital and Research Center,undefined
[17] MBC-J04,undefined
来源
Cancer Cell International | / 22卷
关键词
Nanobodies; Arabian camelid; Biological fluids; Cancers; Therapeutic agents; Diagnosis; And nano proteomics;
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摘要
Cancer is a major health concern and accounts for one of the main causes of death worldwide. Innovative strategies are needed to aid in the diagnosis and treatment of different types of cancers. Recently, there has been an evolving interest in utilizing nanobodies of camel origin as therapeutic tools against cancer. Nanotechnology uses nanobodies an emerging attractive field that provides promises to researchers in advancing different scientific sectors including medicine and oncology. Nanobodies are characteristically small-sized biologics featured with the ability for deep tissue penetration and dissemination and harbour high stability at high pH and temperatures. The current review highlights the potential use of nanobodies that are naturally secreted in camels’ biological fluids, both milk and urine, in the development of nanotechnology-based therapy for treating different typesQuery of cancers and other diseases. Moreover, the role of nano proteomics in the invention of novel therapeutic agents specifically used for cancer intervention is also illustrated.
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