Partial apamin sensitivity of human small conductance Ca2+-activated K+ channels stably expressed in Chinese hamster ovary cells

被引：0

作者：

T. Dale

J. Cryan

M. Chen

D. Trezise

机构：

[1] Ion Channel Biology Group,

[2] Systems Research,undefined

[3] GlaxoSmithKline Research and Development,undefined

[4] Medicines Research Centre,undefined

[5] Gunnels Wood Road,undefined

[6] Stevenage,undefined

[7] Hertfordshire,undefined

[8] SG1 2NY,undefined

[9] UK,undefined

[10] Gene Expression and Protein Biochemistry,undefined

[11] GlaxoSmithKline Research and Development,undefined

[12] Medicines Research Centre,undefined

[13] Gunnels Wood Road,undefined

[14] Stevenage,undefined

[15] Hertfordshire,undefined

[16] SG1 2NY,undefined

[17] UK,undefined

来源：

Naunyn-Schmiedeberg's Archives of Pharmacology | 2002年 / 366卷

关键词：

SK channel Apamin K+ channel Electrophysiology Chinese hamster ovary Ca2+ activated;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The bee venom toxin apamin is an important drug tool for characterising small conductance Ca2+-activated K+ channels (SK channels). In recombinant expression systems both rSK2 and rSK3 channels are potently blocked by apamin, whilst the sensitivity of SK1 channels is somewhat less clear. In the present study we have conducted a detailed analysis by patch clamp electrophysiology of the effects of apamin on human SK channels (SK1, SK2 and SK3) stably expressed in Chinese hamster ovary (CHO-K1) cells.

引用

页码：470 / 477

页数：7

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