Changes of Nitric Oxide Content in the Rat Hippocampus, Heart and Liver in Acute Phase of Ischemia

被引：0

作者：

V. V. Andrianov

S. G. Pashkevich

G. G. Yafarova

A. A. Denisov

V. S. Iyudin

T. Kh. Bogodvid

M. O. Dosina

V. A. Kulchitsky

Kh. L. Gainutdinov

机构：

[1] Zavoisky Physical Technical Institute of the Russian Academy of Sciences,

[2] Kazan Federal University,undefined

[3] Institute of Physiology of National Academy of Sciences of Belarus,undefined

[4] Volga Region State Academy of Physical Culture,undefined

[5] Sport and Tourism,undefined

来源：

Applied Magnetic Resonance | 2016年 / 47卷

关键词：

Nitric Oxide; Nitric Oxide; Electronic Paramagnetic Resonance; Ischemic Stroke; Electronic Paramagnetic Resonance Spectrum;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Electron paramagnetic resonance (EPR) was used as a method to record nitric oxide (NO) production in the tissues of the brain, heart and liver of healthy rats, and rats after modeling of ischemic stroke. Direct measurement of the dynamics of NO production by EPR spectroscopy in our experiments showed that after the emergence of signs of ischemic stroke, 5 h after the start of ischemia, the content of NO in the hippocampus decreased two- to threefold and this decrease was maintained at 24 and 72 h. Deserving special attention is the data demonstrating that there is a greater decrease of NO production in the tissues of the heart and liver than in the brain. Consequently, the change in intensity of NO production in the modeling of ischemic events in the brain has a systemic, not a local character.

引用

页码：965 / 976

页数：11

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