The Rad50 coiled-coil domain is indispensable for Mre11 complex functions

被引：0
|
作者：
Marcel Hohl
Youngho Kwon
Sandra Muñoz Galván
Xiaoyu Xue
Cristina Tous
Andrés Aguilera
Patrick Sung
John H J Petrini
机构：
[1] Laboratory of Chromosome Biology,
[2] Memorial Sloan‐Kettering Cancer Center,undefined
[3] Yale University School of Medicine,undefined
[4] Centro Andaluz de Biología Molecular y Medicina Regenerativa,undefined
[5] Universidad de Sevilla,undefined
来源：
Nature Structural & Molecular Biology | 2011年 / 18卷
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摘要：
Rad50 is part of the Mre11 complex, which plays a central role in DNA damage response and repair. Rad50 has a long coiled-coil region that links its globular DNA-binding domain and hook. Now the role of this region is tested by a series of truncations and functional analyses, which reveal that the HR and NHEJ functions of the Mre11 can be separated.
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页码：1124 / 1131
页数：7
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