4-Hydroxy-2-quinolones 113. Synthesis and antitubercular activity of N-R-amides of 4-hydroxy-6-methyl-2-oxo-1-propyl-1,2,5,6,7,8-hexahydroquinoline- 3-carboxylic acid

被引：0
|
作者：
Ukrainets I.V. [1 ]
Kolesnik E.V. [1 ]
Sidorenko L.V. [1 ]
Gorokhova O.V. [1 ]
Turov A.V. [2 ]
机构：
[1] National Pharmaceutical University
[2] Kiev Taras Shevchenko National University
来源：
Chemistry of Heterocyclic Compounds | 2007年 / 43卷 / 03期
关键词：
4-hydroxy-2-oxoquinoline-3-carboxylic acids; Amides; Antitubercular activity; Thermolysis; X-ray structural analysis;
D O I：
10.1007/s10593-007-0049-2
中图分类号：
学科分类号：
摘要：
A preparative method has been developed and the synthesis has been effected of anilides and heterylamides of 4-hydroxy-6-methyl-2-oxo-1-propyl-1,2,5,6,7,8- hexahydroquinoline-3-carboxylic acid. A comparative analysis has been carried out of the structure and antitubercular properties of the synthesized compounds and their analogs unsubstituted in the quinoline nucleus. © 2007 Springer Science+Business Media, Inc.
引用
收藏
页码：326 / 333
页数：7
相关论文
共 50 条
  • [41] 4-HYDROXY-2-QUINOLONES. 201. SYNTHESIS, STRUCTURE, AND DIURETIC ACTIVITY OF HYDROXY- AND ALKOXYANILIDES OF 6-HYDROXY-2-METHYL-4-OXO-2,4-DIHYDRO-1H-PYRROLO[3,2,1-ij]QUINOLINE-5-CARBOXYLIC ACID
    Ukrainets, I. V.
    Golik, N. Yu.
    Shemchuk, A. L.
    Kravchenko, V. N.
    CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2011, 47 (09) : 1122 - 1127
  • [42] SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF 2-ACETYL-5-HYDROXY-5-METHYL-3-PHENYL-1-CYCLOHEXANONE AND ALKYL-4-HYDROXY-4-METHYL-2-OXO-6-PHENYLCYCLOHEXANE-1-CARBOXYLATES
    Gein, V. L.
    Vagapov, A. V.
    Nosova, N. V.
    Voronina, E. V.
    Vakhrin, M. I.
    Kriven'ko, A. P.
    PHARMACEUTICAL CHEMISTRY JOURNAL, 2010, 44 (05) : 245 - 247
  • [43] Synthesis of 4,N-diaryl-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxamides
    V. L. Gein
    M. I. Kazantseva
    A. A. Kurbatova
    Russian Journal of Organic Chemistry, 2011, 47 : 886 - 888
  • [44] Synthesis and antimicrobial activity of 2-acetyl-5-hydroxy-5-methyl-3-phenyl-1cyclohexanone and alkyl-4-hydroxy-4-methyl2-oxo-6-phenylcyclohexane-1-carboxylates
    V. L. Gein
    A. V. Vagapov
    N. V. Nosova
    E. V. Voronina
    M. I. Vakhrin
    A. P. Kriven’ko
    Pharmaceutical Chemistry Journal, 2010, 44 : 245 - 247
  • [45] 4-Hydroxy-2-quinolones. 39. Structure of 6-bromo-4-hydroxy-1-isoamyl-2-oxo-3-quinolinecarboxylic acid
    Ukrainets I.V.
    Taran S.G.
    Likhanova N.V.
    Jaradat N.A.
    Shishkin O.V.
    Chemistry of Heterocyclic Compounds, 2000, 36 (1) : 57 - 61
  • [46] Synthesis of 4,N-diaryl-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxamides
    Gein, V. L.
    Kazantseva, M. I.
    Kurbatova, A. A.
    RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2011, 47 (06) : 886 - 888
  • [47] 4-hydroxy-2-quinolones. 110. Bromination of 1-R-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid anilides
    Ukrainets, I. V.
    Tkach, A. A.
    Sidorenko, L. V.
    Gorokhova, O. V.
    KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 2006, (10): : 1508 - 1516
  • [48] 4-hydroxy-2-quinolones. 200*. Bromination of 1-R-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid pyridinylmethylene hydrazides
    I. V. Ukrainets
    E. V. Mospanova
    O. V. Gorokhova
    S. V. Shishkina
    Chemistry of Heterocyclic Compounds, 2011, 47 : 1014 - 1019
  • [49] Synthesis of 6-hydroxy-7-methoxy-4-oxo-4H-chromene-2-carboxylic acidN-alkyl amides and their antioxidant activity
    Jungsook Cho
    Hae-Eun Kang
    Jae-Kyung Jung
    Heesoon Lee
    Archives of Pharmacal Research, 2006, 29 : 183 - 187
  • [50] 4-Hydroxy-2-quinolones. 56*. 4-(adamant-1-yl)thiazolyl-2-amides of 1-R-4-hydroxy-2-oxoquinoline-3-carboxylic acids as potential antitubercular agents
    Ukrainets I.V.
    Amer M.
    Bezuglyi P.A.
    Gorokhova O.V.
    Sidorenko L.V.
    Turov A.V.
    Chemistry of Heterocyclic Compounds, 2002, 38 (05) : 571 - 575
12345