Proteomic analysis of the CSF in unmedicated patients with major depressive disorder reveals alterations in suicide attempters

被引：0
|
作者：
J. Brunner
Th. Bronisch
M. Uhr
M. Ising
E. Binder
F. Holsboer
C. W. Turck
机构：
[1] Facharzt für Psychiatrie und Psychotherapie,
来源：
European Archives of Psychiatry and Clinical Neuroscience | 2005年 / 255卷
关键词：
major depressive disorder; suicide attempt; proteomic analysis; cerebrospinal fluid;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
This is the first report on proteomic analysis of the cerebrospinal fluid (CSF) in unmedicated suicide attempters and non-attempters with major depressive disorder.Two-dimensional (2D) gel electrophoresis revealed that suicide attempters differed from non-attempters in one protein with an approximate molecular weight of 33 kD and an isoelectric point of 5.2. Proteomic analysis of the CSF is a promising non hypothesis-driven screening method for the detection of new candidate genes in neurobiological suicide research.
引用
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页码：438 / 440
页数：2
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