Chitosan nanoparticles targeted to the tumor-associated ganglioside GD2

被引：0

作者：

A. A. Zubareva

A. A. Boyko

I. V. Kholodenko

F. N. Rozov

M. V. Larina

T. K. Aliev

I. I. Doronin

P. A. Vishnyakova

I. M. Molotkovskaya

R. V. Kholodenko

机构：

[1] Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences,Institute of Bioengineering

[2] Research Center of Biotechnology of the Russian Academy of Sciences,Belozersky Institute of Physicochemical Biology

[3] Orekhovich Institute of Biomedical Chemistry,Department of Chemistry

[4] Moscow State University,undefined

[5] Moscow State University,undefined

[6] Real Target LLC,undefined

来源：

Russian Journal of Bioorganic Chemistry | 2016年 / 42卷

关键词：

ganglioside GD2; tumor-associated gangliosides; targeted nanoparticles; cell death; monoclonal antibodies; Fab-fragments; scFv-fragments;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Methodological approaches to the creation of nanoparticles based on chitosan derivatives and targeted to the GD2-positive tumor cells were developed. The GD2-specific monoclonal antibodies and their Fab-fragments and scFv-fragments were obtained and studied as vector molecules. Various methods for covalent conjugation of these molecules to the nanoparticles were also studied. It was shown that site-specific conjugation of scFv-fragments of GD2-specific antibodies to the chitosan nanoparticles by using a reagent BMPS is the optimal approach to create targeted chitosan-based nanoparticles directed to tumor-associated ganglioside GD2.

引用

页码：532 / 545

页数：13

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