Biotransformation of Cinobufagin by Cunninghamella elegans

被引：0
|
作者：
Li Qiao
Yu-zhi Zhou
Xiu-lan Qi
Li-hong Lin
Huan Chen
Li-yan Pang
Yue-hu Pei
机构：
[1] School of Traditional Chinese Materia Medica,
[2] Shenyang Pharmaceutical University,undefined
来源：
The Journal of Antibiotics | 2007年 / 60卷
关键词：
biotransformation; cinobufagin; 12α-hydroxybufagin; 11α-hydroxybufagin;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Cunninghamella elegans has been employed for the biotransformation of cinobufagin to afford 5 metabolites. The structures of the transformation products have been characterized as 12α-hydroxybufagin, 11α-hydroxybufagin, 12β-hydroxy-desacetylcinobufagin, 3-oxo-12α-hydroxybufagin and 12β-hydroxybufagin. Products 12α-hydroxybufagin and 11α-hydroxybufagin are new compounds. In vitro both the biotransformation products and cinobufagin all showed cytotoxic activities against HeLa cells.
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页码：261 / 264
页数：3
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