Biotransformation of cinobufagin by Cunninghamella elegans

被引：9
|
作者：
Qiao, Li [1 ]
Zhou, Yu-zhi [1 ]
Qi, Xiu-lan [1 ]
Lin, Li-hong [1 ]
Chen, Huan [1 ]
Pang, Li-yan [1 ]
Pei, Yue-hu [1 ]
机构：
[1] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang 110016, Peoples R China
来源：
JOURNAL OF ANTIBIOTICS | 2007年 / 60卷 / 04期
关键词：
biotransformation; cinobufagin; 12; alpha-hydroxybufagin; 11; Cunninghamella elegans;
D O I：
10.1038/ja.2007.32
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Cunninghamella elegans has been employed for the biotransformation of cinobufagin to afford 5 metabolites. The structures of the transformation products have been characterized as 12 alpha-hydroxybufagin, 11 alpha-hydroxybufagin, 12 beta-hydroxy-desacetyleinobufagin, 3-oxo-12 alpha-hydroxybufagin and 12 beta-hydroxybufagin. Products 12a-hydroxybufagin and 11 alpha-hydroxybufagin are new compounds. In vitro both the biotransformation products and cinobufagin all showed cytotoxic activities against HeLa cells.
引用
收藏
页码：261 / 264
页数：4
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