A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer

被引：0

作者：

Paz Polak

Jaegil Kim

Lior Z Braunstein

Rosa Karlic

Nicholas J Haradhavala

Grace Tiao

Daniel Rosebrock

Dimitri Livitz

Kirsten Kübler

Kent W Mouw

Atanas Kamburov

Yosef E Maruvka

Ignaty Leshchiner

Eric S Lander

Todd R Golub

Aviad Zick

Alexandre Orthwein

Michael S Lawrence

Rajbir N Batra

Carlos Caldas

Daniel A Haber

Peter W Laird

Hui Shen

Leif W Ellisen

Alan D D'Andrea

Stephen J Chanock

William D Foulkes

Gad Getz

机构：

[1] Broad Institute of MIT and Harvard,Department of Radiation Oncology

[2] Massachusetts General Hospital Center for Cancer Research,Division of Molecular Biology, Department of Biology

[3] Harvard Medical School,Department of Radiation Oncology

[4] Memorial Sloan Kettering Cancer Center,Department of Biology

[5] Bioinformatics Group,Department of Systems Biology

[6] Faculty of Science,Departments of Medical Oncology

[7] University of Zagreb,Department of Oncology

[8] Brigham & Women's Hospital and Dana-Farber Cancer Institute,Department of Oncology

[9] MIT,Department of Oncology

[10] Harvard Medical School,Division of Cancer Epidemiology and Genetics

[11] Pathology,Department of Human Genetics

[12] and Pediatric Oncology,Department of Pathology

[13] Dana-Farber Cancer Institute,undefined

[14] Hadassah-Hebrew University Medical Center,undefined

[15] McGill University,undefined

[16] Cancer Research UK Cambridge Institute,undefined

[17] University of Cambridge Li Ka Shing Centre,undefined

[18] Cancer Research UK Cambridge Centre,undefined

[19] University of Cambridge Hutchison–MRC Research Centre,undefined

[20] Cambridge Biomedical Campus,undefined

[21] Van Andel Research Institute,undefined

[22] Center for DNA Damage and Repair,undefined

[23] Dana-Farber Cancer Institute,undefined

[24] Ludwig Center at Harvard,undefined

[25] Harvard Medical School,undefined

[26] US National Cancer Institute,undefined

[27] Lady Davis Institute for Medical Research and Research Institute McGill University Health Centre,undefined

[28] McGill University,undefined

[29] Massachusetts General Hospital,undefined

来源：

Nature Genetics | 2017年 / 49卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Paz Polak, Jaegil Kim, Lior Z. Braunstein and colleagues have identified patterns of genome-wide mutation in certain breast cancers that can be used to identify those with DNA-repair deficiencies that make the tumor more likely to respond to therapies based on PARP inhibitors or platinum. In contrast, oncogenic mutations in several other DNA-repair genes do not generate these patterns.

引用

页码：1476 / 1486

页数：10

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