A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer

被引：0

作者：

Paz Polak

Jaegil Kim

Lior Z Braunstein

Rosa Karlic

Nicholas J Haradhavala

Grace Tiao

Daniel Rosebrock

Dimitri Livitz

Kirsten Kübler

Kent W Mouw

Atanas Kamburov

Yosef E Maruvka

Ignaty Leshchiner

Eric S Lander

Todd R Golub

Aviad Zick

Alexandre Orthwein

Michael S Lawrence

Rajbir N Batra

Carlos Caldas

Daniel A Haber

Peter W Laird

Hui Shen

Leif W Ellisen

Alan D D'Andrea

Stephen J Chanock

William D Foulkes

Gad Getz

机构：

[1] Broad Institute of MIT and Harvard,Department of Radiation Oncology

[2] Massachusetts General Hospital Center for Cancer Research,Division of Molecular Biology, Department of Biology

[3] Harvard Medical School,Department of Radiation Oncology

[4] Memorial Sloan Kettering Cancer Center,Department of Biology

[5] Bioinformatics Group,Department of Systems Biology

[6] Faculty of Science,Departments of Medical Oncology

[7] University of Zagreb,Department of Oncology

[8] Brigham & Women's Hospital and Dana-Farber Cancer Institute,Department of Oncology

[9] MIT,Department of Oncology

[10] Harvard Medical School,Division of Cancer Epidemiology and Genetics

[11] Pathology,Department of Human Genetics

[12] and Pediatric Oncology,Department of Pathology

[13] Dana-Farber Cancer Institute,undefined

[14] Hadassah-Hebrew University Medical Center,undefined

[15] McGill University,undefined

[16] Cancer Research UK Cambridge Institute,undefined

[17] University of Cambridge Li Ka Shing Centre,undefined

[18] Cancer Research UK Cambridge Centre,undefined

[19] University of Cambridge Hutchison–MRC Research Centre,undefined

[20] Cambridge Biomedical Campus,undefined

[21] Van Andel Research Institute,undefined

[22] Center for DNA Damage and Repair,undefined

[23] Dana-Farber Cancer Institute,undefined

[24] Ludwig Center at Harvard,undefined

[25] Harvard Medical School,undefined

[26] US National Cancer Institute,undefined

[27] Lady Davis Institute for Medical Research and Research Institute McGill University Health Centre,undefined

[28] McGill University,undefined

[29] Massachusetts General Hospital,undefined

来源：

Nature Genetics | 2017年 / 49卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Paz Polak, Jaegil Kim, Lior Z. Braunstein and colleagues have identified patterns of genome-wide mutation in certain breast cancers that can be used to identify those with DNA-repair deficiencies that make the tumor more likely to respond to therapies based on PARP inhibitors or platinum. In contrast, oncogenic mutations in several other DNA-repair genes do not generate these patterns.

引用

页码：1476 / 1486

页数：10

共 50 条

[1] A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer
Polak, Paz
Kim, Jaegil
Braunstein, Lior Z.
Karlic, Rosa
Haradhavala, Nicholas J.
Tiao, Grace
Rosebrock, Daniel
Livitz, Dimitri
Kubler, Kirsten
Mouw, Kent W.
Kamburov, Atanas
Maruvka, Yosef E.
Leshchiner, Ignaty
Lander, Eric S.
Golub, Todd R.
Zick, Aviad
Orthwein, Alexandre
Lawrence, Michael S.
Batra, Rajbir N.
Caldas, Carlos
Haber, Daniel A.
Laird, Peter W.
Shen, Hui
Ellisen, Leif W.
D'Andrea, Alan D.
Chanock, Stephen J.
Foulkes, William D.
Getz, Gad
[J]. NATURE GENETICS, 2017, 49 (10) : 1476 - +
[2] A Multiomics Signature Highlights Alterations Underlying Homologous Recombination Deficiency in Triple-Negative Breast Cancer
Su, Guan-Hua
Jiang, Lin
Xiao, Yi
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[J]. ANNALS OF SURGICAL ONCOLOGY, 2022, 29 (11) : 7165 - 7175
[3] ASO Visual Abstract: A Multiomics Signature Highlights Alterations Underlying Homologous Recombination Deficiency in Triple-Negative Breast Cancer
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Yi Xiao
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Yi-Zhou Jiang
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[J]. Annals of Surgical Oncology, 2022, 29 : 7178 - 7179
[4] Analysis of Epigenetic Alterations in Homologous Recombination DNA Repair Genes in Male Breast Cancer
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Nunes, Sandra P.
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Henrique, Rui
Felix, Ana
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[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (08)
[5] Homologous Recombination Repair Gene Alterations Are Associated with Tumor Mutational Burden and Survival of Immunotherapy
Ito, Mamoru
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Oda, Yoshinao
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Baba, Eishi
[J]. CANCERS, 2023, 15 (23)
[6] PARP Inhibition in Prostate Cancer With Homologous Recombination Repair Alterations
von Werdt, Alexander
Brandt, Laura
Scharer, Orlando D.
Rubin, Mark A.
[J]. JCO PRECISION ONCOLOGY, 2021, 5 : 1639 - 1649
[7] Anthracycline-related cardiotoxicity in breast cancer patients carrying mutational signature of homologous recombination deficiency (HRD)
Incorvaia, L.
Fiorino, A.
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Chiari, R.
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Galvano, A.
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Carreca, I. U.
Novo, G.
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[J]. ANNALS OF ONCOLOGY, 2022, 33 (07) : S961 - S962
[8] Anthracycline-related cardiotoxicity in patients with breast cancer harboring mutational signature of homologous recombination deficiency (HRD)
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Badalamenti, G.
Novo, G.
Gori, S.
Cortesi, L.
Brando, C.
Cinieri, S.
Curigliano, G.
Ricciardi, G. R.
Toss, A.
Chiari, R.
Berardi, R.
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Bono, M.
Russo, T. D. Bazan
Gristina, V.
Galvano, A.
Damerino, G.
Blasti, L.
Bazan, V.
Russo, A.
[J]. ESMO OPEN, 2024, 9 (01)
[9] Homologous recombination repair pathway alterations and their relationship to homologous recombination deficiency in advanced pancreatic cancer patients
Patel, Hitendra
Barrett, Alex
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Leibowitz, Benjamin D.
Singhi, Aatur D.
Javle, Milind M.
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[J]. JOURNAL OF CLINICAL ONCOLOGY, 2022, 40 (04)
[10] Bi-allelic alterations in DNA repair genes underpin homologous recombination DNA repair defects in breast cancer
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[J]. JOURNAL OF PATHOLOGY, 2017, 242 (02): : 165 - 177

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