A model for dynamics of primer extension by eukaryotic DNA primase

被引：0
|
作者：
Ping Xie
机构：
[1] Chinese Academy of Sciences,Key Laboratory of Soft Matter Physics and Beijing National Laboratory for Condensed Matter Physics, Institute of Physics
来源：
European Biophysics Journal | 2011年 / 40卷
关键词：
DNA primase; Primer synthesis; Model;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A mathematical model is proposed for processive primer extension by eukaryotic DNA primase. The model uses available experimental data to predict rate constants for the dynamic behavior of primase activity as a function of NTP concentration. The model also predicts some data such as the binding affinities of the primase for the DNA template and for the RNA primer.
引用
收藏
页码：1157 / 1165
页数：8
相关论文
共 50 条
  • [41] Primer synthesis kinetics by Escherichia coli primase on single-stranded DNA templates
    Swart, JR
    Griep, MA
    BIOCHEMISTRY, 1995, 34 (49) : 16097 - 16106
  • [42] WHEAT DNA PRIMASE - RNA PRIMER SYNTHESIS IN-VITRO, STRUCTURAL STUDIES BY PHOTOCHEMICAL CROSS-LINKING, AND MODULATION OF PRIMASE ACTIVITY BY DNA-POLYMERASES
    LAQUEL, P
    LITVAK, S
    CASTROVIEJO, M
    PLANT PHYSIOLOGY, 1994, 105 (01) : 69 - 79
  • [43] Shared Active Site Architecture between the Large Subunit of Eukaryotic Primase and DNA Photolyase
    Sauguet, Ludovic
    Klinge, Sebastian
    Perera, Rajika L.
    Maman, Joseph D.
    Pellegrini, Luca
    PLOS ONE, 2010, 5 (04):
  • [44] The archaeo-eukaryotic primase of plasmid pRN1 requires a helix bundle domain for faithful primer synthesis
    Beck, Kirsten
    Vannini, Alessandro
    Cramer, Patrick
    Lipps, Georg
    NUCLEIC ACIDS RESEARCH, 2010, 38 (19) : 6707 - 6718
  • [45] Dynamics of DNA replication in a eukaryotic cell
    Kelly, Thomas
    Callegari, A. John
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (11) : 4973 - 4982
  • [46] Genetic analysis by primer extension on DNA arrays (apex).
    Pirrung, M
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2000, 220 : U429 - U429
  • [47] DNA replication dynamics: cooperative catalysis by the helicase-primase and the DNA polymerase
    Patel, Smita S.
    Pandey, Manjula
    Ha, Taekjip
    Syed, Salman
    FASEB JOURNAL, 2011, 25
  • [48] Human primase hangs on the primer–template and Polα to facilitate primer termination
    Nature Structural & Molecular Biology, 2023, 30 : 575 - 576
  • [49] RIBO-DEOXYRIBONUCLEOTIDE PRIMER SYNTHESIZED BY PRIMASE
    ROWEN, L
    KORNBERG, A
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1978, 253 (03) : 770 - 774
  • [50] Mechanism of primer synthesis by Primase-Polymerases
    Zabrady, Katerina
    Li, Arthur W. H.
    Doherty, Aidan J.
    CURRENT OPINION IN STRUCTURAL BIOLOGY, 2023, 82
12345