Recombinant HirudinsAn Overview of Recent Developments

被引：0
|
作者：
Uwe Zeymer
机构：
[1] Städtische Kliniken Kassel,
[2] Medizinische Klinik II,undefined
来源：
BioDrugs | 1998年 / 10卷
关键词：
Heparin; Thrombin; Adis International Limited; Acute Myocardial Infarction; Deep Vein Thrombosis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Hirudin is a specific thrombin inhibitor which acts independent of antithrombin III and is able to bind to fluid phase and clot bound thrombin. It has become available for clinical use by production with recombinant techniques just recently. Hirudin produces a relatively stable level of anticoagulation when compared with heparin. However, hirudin is not as effective as heparin in blocking thrombin generation, but is more effective than heparin in inhibiting thrombin activity.
引用
收藏
页码：425 / 436
页数：11
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