Cancer biology and molecular genetics of A3 adenosine receptor

被引：0
|
作者：
Chiara Mazziotta
John Charles Rotondo
Carmen Lanzillotti
Giulia Campione
Fernanda Martini
Mauro Tognon
机构：
[1] University of Ferrara,Laboratories of Cell Biology and Molecular Genetics, Section of Experimental Medicine, Department of Medical Sciences, School of Medicine
[2] University of Ferrara,Center for Studies on Gender Medicine—Department of Medical Sciences
[3] University of Ferrara,Laboratory for Technologies of Advanced Therapies (LTTA)
来源：
Oncogene | 2022年 / 41卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A3 adenosine receptor (A3AR) is a cell membrane protein, which has been found to be overexpressed in a large number of cancer types. This receptor plays an important role in cancer by interacting with adenosine. Specifically, A3AR has a dual nature in different pathophysiological conditions, as it is expressed according to tissue type and stimulated by an adenosine dose-dependent manner. A3AR activation leads to tumor growth, cell proliferation and survival in some cases, while triggering cytostatic and apoptotic pathways in others. This review aims to describe the most relevant aspects of A3AR activation and its ligands whereas it summarizes A3AR activities in cancer. Progress in the field of A3AR modulators, with a potential therapeutic role in cancer treatment are reported, as well.
引用
收藏
页码：301 / 308
页数：7
相关论文
共 50 条
  • [31] Biology and molecular genetics of lung cancer
    Johnson, BE
    Kelley, MJ
    [J]. SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE, 1996, 17 (04) : 299 - 308
  • [32] Targeting the A3 adenosine receptor to treat cytokine release syndrome in cancer immunotherapy
    Cohen, Shira
    Fishman, Pnina
    [J]. DRUG DESIGN DEVELOPMENT AND THERAPY, 2019, 13 : 491 - 497
  • [33] Different efficacy of adenosine and NECA derivatives at the human A3 adenosine receptor: molecular modeling analysis and insight into the receptor activation switch
    Dal Ben, Diego
    Buccioni, Michela
    Lambertucci, Catia
    Marucci, Gabriella
    Spinaci, Andrea
    Thomas, Ajiroghene
    Klotz, Karl-Norbert
    Volpini, Rosaria
    [J]. PURINERGIC SIGNALLING, 2014, 10 (04) : 771 - 771
  • [34] Molecular modeling studies of human A3 adenosine antagonists:: Structural homology and receptor docking
    Moro, S
    Li, AH
    Jacobson, KA
    [J]. JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES, 1998, 38 (06): : 1239 - 1248
  • [35] Synthesis of hypermodified adenosine derivatives as selective adenosine A3 receptor ligands
    Cosyn, L
    Gao, ZG
    Van Rompaey, P
    Lu, CR
    Jacobson, KA
    Van Calenbergh, S
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2006, 14 (05) : 1403 - 1412
  • [36] A3 adenosine receptor allosteric modulator induces an anti-cancer effect in liver cancer
    Cohen, Shira
    Barer, Faina
    Fishman, Pnina
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2014, 34 : S52 - S52
  • [37] Interaction of SSR161421, a novel specific adenosine A3 receptor antagonist with adenosine A3 receptor agonists both in vitro and in vivo
    Mikus, Endre G.
    Boer, Kinga
    Timari, Geza
    Urban-Szabo, Katalin
    Kapui, Zoltan
    Szeredi, Judit
    Gerber, Katalin
    Szabo, Tibor
    Batori, Sandor
    Finet, Michel
    Aranyi, Peter
    Galzin, Anne-Marie
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 2013, 699 (1-3) : 62 - 66
  • [38] Assessment of cardioprotective efficacy of A3 adenosine receptor agonists using mice with cardiac-specific deletion of the A3 adenosine receptor gene
    Wan, Tina
    Tampo, Akihito
    Kwok, Wai-Meng
    Auchampach, John
    [J]. PURINERGIC SIGNALLING, 2014, 10 (04) : 794 - 794
  • [39] THE A3 ADENOSINE RECEPTOR (A3AR) AS A TARGET FOR CANCER TREATMENT: FROM BENCH TO BEDSIDE
    Fishman, P.
    Bar-Yehuda, S.
    Madi, L.
    [J]. ANTICANCER RESEARCH, 2004, 24 (5D) : 3487 - 3487
  • [40] Expression and Function of Adenosine A3 Receptor in the Afferent Arteriole
    Lu, Yan
    Ge, Ying
    Manning, R. Davis
    Liu, Ruisheng
    [J]. HYPERTENSION, 2011, 58 (05) : E139 - E139
12345