Detection of large deletions of mitochondrial DNA in tissues of mice exposed to X-rays

被引：1

作者：

Antipova V.N. ^{[1
]}

Malakhova L.V. ^{[1
]}

Bezlepkin V.G. ^{[1
]}

机构：

[1] Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino

来源：

Biophysics | 2011年 / 56卷 / 3期

关键词：

large deletions; mitochondrial DNA; mouse; X-rays;

D O I：

10.1134/S0006350911030031

中图分类号：

学科分类号：

摘要：

Large mtDNA deletions in mouse brain and spleen cells, induced by X-radiation at doses of 2 and 5 Gy were studied within four weeks after the exposure of animals to X-rays. Variations in the content of extra-cellular deleted mtDNA were examined in the blood plasma of mice irradiated with 5 Gy in the same postir-radiation times. Ionizing radiation was shown to effectively induce large mtDNA deletions at the doses chosen. The level of deletion mtDNA was dependent on dose and postirradiation time. © 2011 Pleiades Publishing, Ltd.

引用

页码：423 / 428

页数：5

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