Detection of large deletions of mitochondrial DNA in tissues of mice exposed to X-rays

被引:1
|
作者
Antipova V.N. [1 ]
Malakhova L.V. [1 ]
Bezlepkin V.G. [1 ]
机构
[1] Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino
关键词
large deletions; mitochondrial DNA; mouse; X-rays;
D O I
10.1134/S0006350911030031
中图分类号
学科分类号
摘要
Large mtDNA deletions in mouse brain and spleen cells, induced by X-radiation at doses of 2 and 5 Gy were studied within four weeks after the exposure of animals to X-rays. Variations in the content of extra-cellular deleted mtDNA were examined in the blood plasma of mice irradiated with 5 Gy in the same postir-radiation times. Ionizing radiation was shown to effectively induce large mtDNA deletions at the doses chosen. The level of deletion mtDNA was dependent on dose and postirradiation time. © 2011 Pleiades Publishing, Ltd.
引用
收藏
页码:423 / 428
页数:5
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