Carbohydrate recognition by Clostridium difficile toxin A

被引：0

作者：

Antonio Greco

Jason G S Ho

Shuang-Jun Lin

Monica M Palcic

Maja Rupnik

Kenneth K-S Ng

机构：

[1] Alberta Ingenuity Centre for Carbohydrate Science,Department of Biological Sciences

[2] University of Calgary,Department of Chemistry

[3] University of Calgary,undefined

[4] University of Alberta,undefined

[5] Institute of Public Health,undefined

[6] The Carlsberg Laboratory,undefined

[7] School of Pharmacy,undefined

[8] University of Wisconsin,undefined

来源：

Nature Structural & Molecular Biology | 2006年 / 13卷

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D O I：

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学科分类号：

摘要：

Clostridium difficile TcdA is a large toxin that binds carbohydrates on intestinal epithelial cells. A 2-Å resolution cocrystal structure reveals two molecules of α-Gal-(1,3)-β-Gal-(1,4)-β-GlcNAcO(CH2)8CO2CH3 binding in an extended conformation to TcdA. Residues forming key contacts with the trisaccharides are conserved in all seven putative binding sites in TcdA, suggesting a mode of multivalent binding that may be exploited for the rational design of novel therapeutics.

引用

页码：460 / 461

页数：1

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