Development of an Experimental Model of Cardiac Failure Combined with Type I Diabetes Mellitus

被引：0
|
作者：
S. A. Afanasiev
D. S. Kondratyeva
S. V. Popov
机构：
[1] Siberian Division of the Russian Academy of Medical Sciences,Institute of Cardiology, Tomsk Research Center
来源：
Bulletin of Experimental Biology and Medicine | 2012年 / 153卷
关键词：
heart failure; type 1 diabetes mellitus; streptozotocin; coronary occlusion;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The doses and mode of streptozotocin injection for modeling heart failure combined with type 1 diabetes mellitus have been determined. Combined disease was induced in animals by injecting the selected streptozotocin dose (60 mg/kg intraperitoneally) at the stage of heart failure formation (2 weeks after coronary occlusion). This protocol of experiment led to development of hyperglycemia, body weight loss, and formation of myocardial cicatrix and hypertrophy corresponding to signs of heart failure paralleled by diabetes mellitus.
引用
收藏
页码：530 / 532
页数：2
相关论文
共 50 条
  • [21] Development of Type I Diabetes Mellitus in an Older Patient with Gastric Cancer
    不详
    JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2022, 70 : S166 - S167
  • [22] The peculiarities of development and course of distal polyneuropathy in diabetes mellitus type I
    Mitrofanova, I. N.
    Skvortsova, V. I.
    ZHURNAL NEVROLOGII I PSIKHIATRII IMENI S S KORSAKOVA, 2008, 108 (06) : 11 - 17
  • [23] Development of Prediction Model to Estimate the Risk of Heart Failure in Diabetes Mellitus
    Qu, Hongling
    Wu, Cuiyun
    Ye, Peiji
    Lv, Weibiao
    FRONTIERS IN CARDIOVASCULAR MEDICINE, 2022, 9
  • [24] The prevention of type I diabetes mellitus
    Julius, MC
    Schatz, DA
    Silverstein, JH
    PEDIATRIC ANNALS, 1999, 28 (09): : 585 - +
  • [25] Prevention of type I diabetes mellitus
    不详
    DIABETES CARE, 1996, 19 : S45 - S45
  • [26] Preventing type I diabetes mellitus
    Laron, Z
    ISRAEL MEDICAL ASSOCIATION JOURNAL, 2004, 6 (12): : 787 - 787
  • [27] Epidemiology of type I diabetes mellitus
    Rewers, M
    Norris, J
    Dabelea, D
    IMMUNOLOGY OF TYPE 1 DIABETES, SECOND EDITION, 2004, 552 : 219 - 246
  • [28] Mucosal inflammation in a genetic model of spontaneous type I diabetes mellitus
    Hardin, JA
    Donegan, L
    Woodman, RC
    Trevenen, C
    Gall, DG
    CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2002, 80 (11) : 1064 - 1070
  • [29] Dual-parameter model for prediction of type I diabetes mellitus
    Eisenbarth, GS
    Gianani, R
    Yu, LP
    Pietropaolo, M
    Verge, CF
    Chase, HP
    Redondo, MJ
    Colman, P
    Harrison, L
    Jackson, R
    PROCEEDINGS OF THE ASSOCIATION OF AMERICAN PHYSICIANS, 1998, 110 (02) : 126 - 135
  • [30] INFLUENCE OF CHRONIC CARDIAC FAILURE SEVERITY ON THE COURSE OF COMORBID TYPE 2 DIABETES MELLITUS
    Narusov, O. Yu
    Lapina, Yu V.
    Mareev, V. Yu
    Bolotina, M. G.
    Shestakova, M. V.
    Masenko, V. P.
    Baklanova, N. A.
    Belenkov, Yu V.
    TERAPEVTICHESKII ARKHIV, 2009, 81 (09) : 52 - 57
12345