Organic anion transporting polypeptides OATP1B1 and OATP1B3 and their genetic variants influence the pharmacokinetics and pharmacodynamics of raloxifene

被引:0
|
作者
Tina Trdan Lušin
Bruno Stieger
Janja Marc
Aleš Mrhar
Jurij Trontelj
Andrej Zavratnik
Barbara Ostanek
机构
[1] University of Ljubljana,Department of Biopharmacy and Pharmacokinetics, Faculty of Pharmacy
[2] University Hospital Zürich,Department of Clinical Pharmacology and Toxicology
[3] University of Ljubljana,Department of Clinical Biochemistry, Faculty of Pharmacy
[4] University Medical Centre,Department of Endocrinology and Diabetology
关键词
Raloxifene; Raloxifene diglucuronide; SLCO1B1; SLCO1B3; Osteoporosis; LC/MS/MS;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [31] Clinical Importance of OATP1B1 and OATP1B3 in Drug-Drug Interactions
    Shitara, Yoshihisa
    DRUG METABOLISM AND PHARMACOKINETICS, 2011, 26 (03) : 220 - 227
  • [32] Contribution of OATP1B1 and OATP1B3 to the Disposition of Sorafenib and Sorafenib-Glucuronide
    Zimmerman, Eric I.
    Hu, Shuiying
    Roberts, Justin L.
    Gibson, Alice A.
    Orwick, Shelley J.
    Li, Lie
    Sparreboom, Alex
    Baker, Sharyn D.
    CLINICAL CANCER RESEARCH, 2013, 19 (06) : 1458 - 1466
  • [33] Human organic anion transporting polypeptide 1B3 (OATP1B3) is more heavily N-glycosylated than OATP1B1 in extracellular loops 2 and 5
    Liang, Ting
    Liu, Han
    Li, Lanjing
    Huan, Ru
    Gui, Chunshan
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2024, 278
  • [34] Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans
    Hirano, M
    Maeda, K
    Shitara, Y
    Sugiyama, Y
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2004, 311 (01): : 139 - 146
  • [35] OATP1B3 Expression and Function is Modulated by Coexpression with OCT1, OATP1B1, and NTCP
    Zhang, Yuchen
    Ruggiero, Melissa
    Hagenbuch, Bruno
    DRUG METABOLISM AND DISPOSITION, 2020, 48 (08) : 622 - 630
  • [36] Pyranine-based Dyes as a Sensitive Tool to Investigate Drug/Food Interactions of Organic Anion Transporting Polypeptides, OATP1B1/3 and OATP2B1
    Ungvari, Orsolya
    Kiraly, Laura
    Szekely, Virag
    Poor, Miklos
    Bakos, Eva
    Ozvegy-Laczka, Csilla
    FASEB JOURNAL, 2021, 35
  • [37] Digoxin Is Not a Substrate for Organic Anion-Transporting Polypeptide Transporters OATP1A2, OATP1B1, OATP1B3, and OATP2B1 but Is a Substrate for a Sodium-Dependent Transporter Expressed in HEK293 Cells
    Taub, Mitchell E.
    Mease, Kirsten
    Sane, Rucha S.
    Watson, Cory A.
    Chen, Liangfu
    Ellens, Harma
    Hirakawa, Brad
    Reyner, Eric L.
    Jani, Marton
    Lee, Caroline A.
    DRUG METABOLISM AND DISPOSITION, 2011, 39 (11) : 2093 - 2102
  • [38] Nuclear receptor ligands interact with the human liver transporters OATP1B1 and OATP1B3
    Hagenbuch, BH
    Obaidat, A
    Thompson, L
    FASEB JOURNAL, 2006, 20 (05): : A1143 - A1143
  • [39] Transport by OATP1B1 and OATP1B3 enhances cytotoxicity of EGCG and certain substituted quercetins
    Zhang, Yuchen
    Hays, Amanda
    Noblett, Alexander
    Thapa, Mahendra
    Hua, Duy H.
    Hagenbuch, Bruno
    FASEB JOURNAL, 2013, 27
  • [40] Assessing Trans-Inhibition of OATP1B1 and OATP1B3 by Calcineurin and/or PPIase Inhibitors and Global Identification of OATP1B1/3-Associated Proteins
    Powell, John T.
    Kayesh, Ruhul
    Ballesteros-Perez, Alexandra
    Alam, Khondoker
    Niyonshuti, Pascaline
    Soderblom, Erik J.
    Ding, Kai
    Xu, Chao
    Yue, Wei
    PHARMACEUTICS, 2024, 16 (01)