Hydroxylation of a conserved tRNA modification establishes non-universal genetic code in echinoderm mitochondria

被引：0
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作者：
Asuteka Nagao
Mitsuhiro Ohara
Kenjyo Miyauchi
Shin-ichi Yokobori
Akihiko Yamagishi
Kimitsuna Watanabe
Tsutomu Suzuki
机构：
[1] Graduate School of Engineering,Department of Chemistry and Biotechnology
[2] University of Tokyo,Department of Applied Life Sciences
[3] School of Life Sciences,undefined
[4] Tokyo University of Pharmacy and Life Sciences,undefined
来源：
Nature Structural & Molecular Biology | 2017年 / 24卷
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摘要：
In echinoderm mitochondria, the codon AAA encodes asparagine instead of lysine. A newly identified nucleoside modification, hydroxy-N6-threonylcarbamoyladenosine (ht6A), is found adjacent to the anticodon in mt-tRNALys and prevents mt-tRNALys from misreading AAA as lysine.
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页码：778 / 782
页数：4
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