Synthesis and Neurotropic Activity of 8-Amino Derivatives of Condensed Thieno[3,2-d]- and Furo[3,2-d]Pyrimidines

被引：0
|
作者：
S. N. Sirakanyan
A. A. Ovakimyan
A. S. Noravyan
N. S. Minasyan
I. A. Dzhagatspanyan
I. M. Nazaryan
A. G. Akopyan
机构：
[1] National Academy of Sciences of Armenia,Mndjoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
[2] National Academy of Sciences of Armenia,Molecular Structure Research Center, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
来源：
Pharmaceutical Chemistry Journal | 2014年 / 47卷
关键词：
pyrano[3,4-; ]pyridines; thieno[3,2-; ]pyrimidines; furo[3,2-; ]pyrimidines; cyclization; amino derivatives; neurotropic activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
New derivatives of pyrano[4″,3″:4′,5′]pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidines based on 3-chloro derivatives of pyrano[3,4-c]pyridines and pyrano[4″,3″:4′,5′]pyrido[3′,2′:4,5]furo[3,2-d]pyrimidines based on previously prepared 8-chloro derivatives were synthesized. Studies of the biological activity of the synthesized compounds showed that several of them exhibited neurotropic properties.
引用
收藏
页码：655 / 659
页数：4
相关论文
共 50 条
  • [41] Synthesis and evaluation of thieno[3,2-d]pyrimidine derivatives as novel FMS inhibitors
    Kim, Yu-Yon
    Choi, Jaeyul
    Choi, Kyungjin
    Park, Changhee
    Kim, Young Hoon
    Suh, Kwee Hyun
    Ham, Young Jin
    Jang, Sun Young
    Lee, Kyu-Hang
    Hwang, Kwang Woo
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2019, 29 (02) : 271 - 275
  • [42] SYNTHESIS OF FURO[3,2-D]PYRIMIDINE C-NUCLEOSIDES
    BHATTACHARYA, BK
    LIM, MI
    OTTER, BA
    KLEIN, RS
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1986, 191 : 5 - CARB
  • [43] 4-Substituted Thieno[3,2-d]pyrimidines as Dual-Stage Antiplasmodial Derivatives
    Lagardere, Prisca
    Mustiere, Romain
    Amanzougaghene, Nadia
    Hutter, Sebastien
    Franetich, Jean-Francois
    Azas, Nadine
    Vanelle, Patrice
    Verhaeghe, Pierre
    Primas, Nicolas
    Mazier, Dominique
    Masurier, Nicolas
    Lisowski, Vincent
    PHARMACEUTICALS, 2022, 15 (07)
  • [44] ADVANCES OF CHEMISTRY OF PYRROLO[3,2-D]PYRIMIDINES
    GLUSHKOV, RG
    SIZOVA, OS
    KHIMIKO-FARMATSEVTICHESKII ZHURNAL, 1986, 20 (06): : 713 - 727
  • [45] Synthesis of Novel Thieno[3,2-b]quinolines and Thieno[3,2-d][1,3]thiazoles
    Datoussaid, Yazid
    Kirsch, Gilbert
    Othman, Adil A.
    Abdillahi, Ismail
    SOUTH AFRICAN JOURNAL OF CHEMISTRY-SUID-AFRIKAANSE TYDSKRIF VIR CHEMIE, 2012, 65 : 223 - 227
  • [46] NEW SYNTHESES OF PYRIDO[3,2-D]PYRIMIDINES
    SENGA, K
    FUKAMI, K
    KANAZAWA, H
    NISHIGAKI, S
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 1982, 19 (04) : 805 - 808
  • [47] SYNTHESIS OF BENZO(1)THENO(2,3-D)PYRIMIDINES AND BENZO(1)THIENO(3,2-D)PYRIMIDINES
    ROBBA, M
    RIQUELME, RM
    TOUZOT, P
    TETRAHEDRON LETTERS, 1972, (44) : 4549 - &
  • [48] Synthesis of Hexa- and Octahydropyrido[3'2':4,5]thieno[3,2-d]pyrimidines
    V. V. Dotsenko
    S. G. Krivokolysko
    V. P. Litvinov
    Chemistry of Heterocyclic Compounds, 2003, 39 (1) : 110 - 112
  • [49] Synthesis of hexa- and octahydropyrido[3′,2′:4,5]thieno[3,2-d]pyrimidines
    Dotsenko, VV
    Krivokolysko, SG
    Litvinov, VP
    KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 2003, (01): : 117 - 119
  • [50] Simple approach to thieno[3,2-d]pyrimidines as new scaffolds of antimicrobial activities
    Hafez, Hend N.
    El-Gazzar, Abdel-Rhman B. A.
    Zaki, Magdi E. A.
    ACTA PHARMACEUTICA, 2016, 66 (03) : 331 - 351
12345