Novel roles of RNA-binding proteins in drug resistance of breast cancer: from molecular biology to targeting therapeutics

被引：0

作者：

Yinghuan Cen

Letian Chen

Zihao Liu

Qun Lin

Xiaolin Fang

Herui Yao

Chang Gong

机构：

[1] Sun Yat-Sen Memorial Hospital,Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation

[2] Sun Yat-Sen University,Breast Tumor Center

[3] Sun Yat-Sen Memorial Hospital,Department of Breast and Thyroid Surgery, Shenzhen People’s Hospital

[4] Sun Yat-Sen University,undefined

[5] The Second Clinical Medical College of Jinan University,undefined

[6] The First Affiliated Hospital of Southern University of Science and Technology,undefined

来源：

Cell Death Discovery | / 9卷

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摘要：

Therapy resistance remains a huge challenge for current breast cancer treatments. Exploring molecular mechanisms of therapy resistance might provide therapeutic targets for patients with advanced breast cancer and improve their prognosis. RNA-binding proteins (RBPs) play an important role in regulating therapy resistance. Here we summarize the functions of RBPs, highlight their tremendously important roles in regulating therapy sensitivity and resistance and we also reveal current therapeutic approaches reversing abnormal functions of RBPs in breast cancer.

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