Synthesis and Biological Activity of Nitrilic Derivatives of the Methyl Ester of Maleopimaric Acid

被引：0
|
作者：
E. V. Tret’yakova
E. V. Salimova
L. V. Parfenova
机构：
[1] Russian Academy of Sciences,Institute of Petrochemistry and Catalysis
来源：
Russian Journal of Bioorganic Chemistry | 2018年 / 44卷
关键词：
diterpenoids; levopimaric acid; maleopimaric acid; methyl ester; cytotoxic activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
An effective method of a modification of the anhydride ring of the maleopimaric acid methyl ester by means of the cyanoethylation reaction was developed. A primary screening of a cytotoxic activity in vitro demonstrated an ability of the cyanoethyl derivative of the maleopimaric acid methyl ester to induce the death of the PC-3 cells of prostate cancer.
引用
收藏
页码：547 / 552
页数：5
相关论文
共 50 条
  • [21] Synthesis and Spectral Characteristics of Hydrazinocarbonothioyl Derivatives of Maleopimaric Acid
    G. F. Vafina
    A. I. Poptsov
    Russian Journal of General Chemistry, 2023, 93 : 1955 - 1965
  • [22] SYNTHESIS OF DEUTERIUM AND TRITIUM LABELED DERIVATIVES OF MALEOPIMARIC ACID
    RAMM, PJ
    TAYLOR, JB
    JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 1976, 12 (01): : 13 - 22
  • [23] Synthesis and Spectral Characteristics of Quinoline Derivatives of Maleopimaric Acid
    G. F. Vafina
    O. V. Akchurina
    A. N. Lobov
    Russian Journal of General Chemistry, 2023, 93 : 2217 - 2223
  • [24] Synthesis and antiviral activity of maleopimaric and quinopimaric acids' derivatives
    Tretyakova, Elena V.
    Smirnova, Irina E.
    Salimova, Elena V.
    Odinokov, Victor N.
    BIOORGANIC & MEDICINAL CHEMISTRY, 2015, 23 (20) : 6543 - 6550
  • [25] Synthesis of 3-Methyl Derivatives from Dihydrobetulonic Acid Methyl Ester
    G. F. Krainova
    Yu. A. Beloglazova
    V. V. Grishko
    Chemistry of Natural Compounds, 2023, 59 : 80 - 86
  • [26] Synthesis of 3-Methyl Derivatives from Dihydrobetulonic Acid Methyl Ester
    Krainova, G. F.
    Beloglazova, Yu. A.
    Grishko, V. V.
    CHEMISTRY OF NATURAL COMPOUNDS, 2023, 59 (01) : 80 - 86
  • [27] Synthesis and Biological Activities of Tyrosol Phenolic Acid Ester Derivatives
    Hao Zang
    Peng Shen
    Qian Xu
    Luyun Zhang
    Guangqing Xia
    Jiaming Sun
    Junyi Zhu
    Xiaohong Yang
    Chemistry of Natural Compounds, 2019, 55 : 1043 - 1049
  • [28] Synthesis and Biological Activities of Tyrosol Phenolic Acid Ester Derivatives
    Zang, Hao
    Shen, Peng
    Xu, Qian
    Zhang, Luyun
    Xia, Guangqing
    Sun, Jiaming
    Zhu, Junyi
    Yang, Xiaohong
    CHEMISTRY OF NATURAL COMPOUNDS, 2019, 55 (06) : 1043 - 1049
  • [29] Synthesis and Antimicrobial Activity of Ursolic Acid Ester Derivatives
    Pereira, Vinicius Viana
    Pereira, Nara Rubia
    Pereira, Rafael Cesar Goncalves
    Duarte, Lucienir Pains
    Takahashi, Jacqueline Aparecida
    Silva, Roqueline Rodrigues
    CHEMISTRY & BIODIVERSITY, 2022, 19 (01)
  • [30] Synthesis and Biological Activity of Lycorine Derivatives Containing Malate Ester
    Zhao Ying
    Qiao Ling
    Zhao Guofeng
    Chen Li
    CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE, 2021, 42 (09): : 2789 - 2797
12345