mRNA in cancer immunotherapy: beyond a source of antigen

被引：0
|
作者：
Lien Van Hoecke
Rein Verbeke
Heleen Dewitte
Ine Lentacker
Karim Vermaelen
Karine Breckpot
Sandra Van Lint
机构：
[1] VIB-UGent Center for Inflammation Research,Department of Biomedical Molecular Biology
[2] Ghent University,Ghent Research Group on Nanomedicines, Lab for General Biochemistry and Physical Pharmacy, Department of Pharmaceutical Sciences
[3] Ghent University,Cancer Research Institute Ghent (CRIG)
[4] Ghent University,Tumor Immunology Laboratory, Department of Respiratory Medicine and Immuno
[5] Ghent University Hospital,Oncology Network Ghent
[6] Vrije Universiteit Brussel,Laboratory for Molecular and Cellular Therapy, Department of Biomedical Sciences
来源：
Molecular Cancer | / 20卷
关键词：
Cancer; mRNA; Nanoparticle; Antibody; Dendritic cell; T cell; Cytokine; Tumor microenvironment;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
mRNA therapeutics have become the focus of molecular medicine research. Various mRNA applications have reached major milestones at high speed in the immuno-oncology field. This can be attributed to the knowledge that mRNA is one of nature’s core building blocks carrying important information and can be considered as a powerful vector for delivery of therapeutic proteins to the patient.
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