Cytochrome P450–catalyzed L-tryptophan nitration in thaxtomin phytotoxin biosynthesis

被引：0

作者：

Sarah M Barry

Johan A Kers

Evan G Johnson

Lijiang Song

Philip R Aston

Bhumit Patel

Stuart B Krasnoff

Brian R Crane

Donna M Gibson

Rosemary Loria

Gregory L Challis

机构：

[1] University of Warwick,Department of Chemistry

[2] Cornell University,Department of Plant Pathology and Plant

[3] Cornell University,Microbe Biology

[4] Agricultural Research Service,Department of Chemistry and Chemical Biology

[5] Robert W. Holley Center for Agriculture and Health,United States Department of Agriculture

[6] Present addresses: Department of Chemistry,undefined

[7] School of Biomedical Sciences,undefined

[8] King's College London,undefined

[9] London,undefined

[10] UK (S.M.B.); Industrial Products Division,undefined

[11] Intrexon Corporation,undefined

[12] San Carlos,undefined

[13] California,undefined

[14] USA (J.A.K.); Citrus Research and Education Center,undefined

[15] University of Florida,undefined

[16] Lake Alfred,undefined

[17] Florida,undefined

[18] USA (E.G.J.); Fraunhofer USA Center for Molecular Biotechnology,undefined

[19] Newark,undefined

[20] Delaware,undefined

[21] USA (B.P.); Plant Pathology Department,undefined

[22] University of Florida,undefined

[23] Gainesville,undefined

[24] Florida,undefined

[25] USA (R.L.).,undefined

来源：

Nature Chemical Biology | 2012年 / 8卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The mechanism for nitro group formation in the thaxtomin family of natural products is unknown. Genetic and biochemical studies now show the cytochrome P450 TxtE catalyzes this direct and regioselective nitration, using NO and O2 to modify a tryptophan indole ring.[graphic not available: see fulltext]

引用

页码：814 / 816

页数：2

共 50 条

[31] Bifunctional Cytochrome P450 Enzymes Involved in Camptothecin Biosynthesis
Yang, Yun
Li, Wei
Pang, Jing
Jiang, Liangzhen
Qu, Xixing
Pu, Xiang
Zhang, Guolin
Luo, Yinggang
ACS CHEMICAL BIOLOGY, 2019, 14 (06) : 1091 - 1096
[32] Tailoring Reactions Catalyzed by Heme-Dependent Enzymes: Spectroscopic Characterization of the L-Tryptophan-Nitrating Cytochrome P450 TxtE
Barry, Sarah M.
Challis, Gregory L.
NATURAL PRODUCT BIOSYNTHESIS BY MICROORGANISMS AND PLANTS, PT B, 2012, 516 : 171 - 194
[33] Cytochrome p450 recognition sites for NADPH cytochrome p450 reductase
Dai, R
Robinson, RC
Friedman, FK
BIOPHYSICAL JOURNAL, 1996, 70 (02) : SU162 - SU162
[34] Measurement of cytochrome P450 and NADPH-cytochrome P450 reductase
Guengerich, F. Peter
Martin, Martha V.
Sohl, Christal D.
Cheng, Qian
NATURE PROTOCOLS, 2009, 4 (09) : 1245 - 1251
[35] The influence of tryptophan-deficient diet on liver cytochrome P450
Marta Kot
Andrzej Pilc
Władysława Anna Daniel
Pharmacological Reports, 2012, 64 : 483 - 483
[36] The influence of tryptophan-deficient diet on liver cytochrome P450
Kot, Marta
Pilc, Andrzej
Daniel, Wladyslawa Anna
PHARMACOLOGICAL REPORTS, 2012, 64 (02) : 483 - 483
[37] Coexpression in yeast of Taxus cytochrome p450 reductase with cytochrorne P450 oxygenases involved in taxol biosynthesis
Jennewein, S
Park, H
DeJong, JM
Long, RM
Bollon, AP
Croteau, RB
BIOTECHNOLOGY AND BIOENGINEERING, 2005, 89 (05) : 588 - 598
[38] Mechanism of oxidation reactions catalyzed by cytochrome P450 enzymes
Meunier, B
de Visser, SP
Shaik, S
CHEMICAL REVIEWS, 2004, 104 (09) : 3947 - 3980
[39] Bacterial Cytochrome P450 Catalyzed Macrocyclization of Ribosomal Peptides
Liu, Jing
Liu, Runze
He, Bei-Bei
Lin, Xiaoqian
Guo, Longcheng
Wu, Gengfan
Li, Yong-Xin
ACS BIO & MED CHEM AU, 2024, 4 (06): : 268 - 279
[40] Computational Biotransformation Profile of Paracetamol Catalyzed by Cytochrome P450
Ji, Li
Schueuermann, Gerrit
CHEMICAL RESEARCH IN TOXICOLOGY, 2015, 28 (04) : 585 - 596

← 1 2 3 4 5 →